J
Joann Labruyere
Researcher at Washington University in St. Louis
Publications - 34
Citations - 6242
Joann Labruyere is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Glutamate receptor & Phencyclidine. The author has an hindex of 27, co-authored 34 publications receiving 6059 citations.
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Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs
TL;DR: These findings raise new questions regarding the safety of these agents in the clinical management of neurodegenerative diseases and reinforce concerns about the potential risks associated with illicit use of PCP.
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NMDA Antagonist Neurotoxicity: Mechanism and Prevention
TL;DR: It is shown that the morphological damage can be prevented by certain anticholinergic drugs or by diazepam and barbiturates, which act at the gamma-aminobutyric acid (GABA) receptor-channel complex and are known to suppress the psychotomimetic symptoms caused by ketamine, thereby enhancing their utility as neuroprotective drugs.
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Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain.
Chainllie Young,Vesna Jevtovic-Todorovic,Yue-Qin Qin,Tatyana Tenkova,Haihui Wang,Joann Labruyere,John W. Olney +6 more
TL;DR: It is concluded that relatively mild exposure to ketamine, midazolam or a combination of these drugs can trigger apoptotic neurodegeneration in the developing mouse brain.
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Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity
TL;DR: There may be a period during development when NMA receptors are hypersensitive to excitotoxic stimulation, thus rendering the neurons possessing such receptors hypervulnerable to hypoxic/ischemic brain damage.
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The role of specific ions in glutamate neurotoxicity
TL;DR: The neurotoxic action of Glu on retinal neurons is dependent on the presence of Na+ and Cl-, but not Ca2+, in the incubation medium, and depolarizing concentrations of K+ can induce a severe cytotoxic reaction in chick retina.