J
Joanne Brown
Researcher at University of Cambridge
Publications - 7
Citations - 514
Joanne Brown is an academic researcher from University of Cambridge. The author has contributed to research in topics: Parkinson's disease & Dementia. The author has an hindex of 5, co-authored 7 publications receiving 467 citations.
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Journal ArticleDOI
Tau and α-synuclein in susceptibility to, and dementia in, Parkinson's disease
An Goris,An Goris,Caroline H. Williams-Gray,Graeme R. Clark,Thomas Foltynie,Simon J.G. Lewis,Joanne Brown,Maria Ban,Maria Grazia Spillantini,Alastair Compston,David J. Burn,Patrick F. Chinnery,Roger A. Barker,Stephen Sawcer +13 more
TL;DR: The genetic basis of susceptibility to and cognitive heterogeneity of Parkinson's disease is investigated and it is found that the former is linked to higher levels of cognitive impairment and the latter to decreased mobility.
Journal ArticleDOI
The utility of the Cambridge Behavioural Inventory in neurodegenerative disease
Catherine J. Wedderburn,Helen J. Wear,Joanne Brown,Sarah J Mason,Roger A. Barker,John R. Hodges,Caroline H. Williams-Gray +6 more
TL;DR: The CBI is a robust, easy-to-use and valid instrument, which has the capacity to discriminate between neurodegenerative diseases, and may be of value in monitoring therapeutic interventions.
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When is it safe to return to driving following first-ever seizure?
TL;DR: The data provide a quantitative approach to decisions regarding a return to driving in patients with first-ever provoked or unprovoked seizure and help balance the occupational, educational and social limitations that result from patients being ineligible to drive.
Journal ArticleDOI
Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort
Caroline H. Williams-Gray,An Goris,Thomas Foltynie,Joanne Brown,Melanie Maranian,Amie Walton,D. A. S. Compston,Stephen Sawcer,Roger A. Barker +8 more
TL;DR: The LRRK2 G2019S mutation frequency was determined in an unselected, community based cohort of idiopathic PD cases from the UK and phenotypic characteristics among carriers were described, with important implications for genetic screening in the clinical field.
Journal ArticleDOI
Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease.
An Goris,Caroline H. Williams-Gray,Thomas Foltynie,Joanne Brown,Melanie Maranian,Amie Walton,D. A. S. Compston,Roger A. Barker,Stephen Sawcer +8 more
TL;DR: An indirect association analysis of TGFB2 using 8 haplotype-tagging SNPs in a population of 937 MS patients, 538 PD cases and 2022 controls found no evidence for association with susceptibility or progression of MS, but demonstrated a trend towards association of the 5’ region of the gene with susceptibility to PD.