J
Joannes J.M. Marx
Researcher at Utrecht University
Publications - 64
Citations - 2055
Joannes J.M. Marx is an academic researcher from Utrecht University. The author has contributed to research in topics: Hemochromatosis & Hereditary hemochromatosis. The author has an hindex of 26, co-authored 63 publications receiving 1961 citations. Previous affiliations of Joannes J.M. Marx include Radboud University Nijmegen & University Medical Center Utrecht.
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Journal ArticleDOI
The concept of iron bioavailability and its assessment.
TL;DR: A broad overview of historical and current methods for the assessment of iron bioavailability was given, which can be divided into iron solubility studies, iron absorption studies, endpoint measures, and arithmetic models.
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Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo
T M Rooyakkers,T M Rooyakkers,Erik S. G. Stroes,M P Kooistra,E.E. van Faassen,Robert C. Hider,Ton J. Rabelink,Joannes J.M. Marx +7 more
TL;DR: Intravenous iron supplementation is used widely in haemodialysis patients and nontransferrin‐bound iron, which increases after intravenous supplementation of ferric saccharate, has been suggested to act as a catalytic agent in oxygen radical formation in vitro and may thus contribute to endothelial impairment in vivo.
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Hereditary Hemochromatosis: Genetic Complexity and New Diagnostic Approaches
TL;DR: New insights in mechanisms of iron overload are described, which are needed to understand new developments in diagnostic medicine and design innovative and reliable DNA and protein tests for diagnosis.
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Iron Release From Human Monocytes After Erythrophagocytosis In Vitro: An Investigation in Normal Subjects and Hereditary Hemochromatosis Patients
TL;DR: A high percentage of the total amount of iron was released both by viable normal and HH monocytes, suggesting that iron release as Hb is a physiologic process, which may occur whenever the erythrocyte-processing capacity of macrophages is exceeded.
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Non‐transferrin‐bound iron is present in serum of hereditary haemochromatosis heterozygotes
TL;DR: This work investigated whether sera of HH heterozygotes contain more NTBI thanSera of normal controls, and found that non‐transferrin‐bound iron (NTBI) is found in serum, which can catalyze lipid peroxidation in iron overload conditions.