R
Robert C. Hider
Researcher at King's College London
Publications - 517
Citations - 21855
Robert C. Hider is an academic researcher from King's College London. The author has contributed to research in topics: Transferrin & Transferrin saturation. The author has an hindex of 69, co-authored 508 publications receiving 19884 citations. Previous affiliations of Robert C. Hider include University of Leicester & Johns Hopkins University Applied Physics Laboratory.
Papers
More filters
Journal ArticleDOI
Chemistry and biology of siderophores.
Robert C. Hider,Xiaole Kong +1 more
TL;DR: The classification and chemical properties of siderophores are described, before outlining research on sidersophore biosynthesis and transport and Clinically important siderophile design and the therapeutic potential are described.
Journal ArticleDOI
Identification of an intestinal heme transporter.
M Shayeghi,Gladys O. Latunde-Dada,Jonathan S. Oakhill,Abas H. Laftah,Ken Takeuchi,Neil Halliday,Yasmin Khan,Alice Warley,Fiona E. McCann,Robert C. Hider,David M. Frazer,Gregory J. Anderson,Chris D. Vulpe,Robert J. Simpson,Andrew T. McKie +14 more
TL;DR: A membrane protein named HCP 1 (heme carrier protein 1), with homology to bacterial metal-tetracycline transporters, mediates heme uptake by cells in a temperature-dependent and saturable manner and is indicated to be the long-sought intestinal heme transporter.
Journal ArticleDOI
Nicotianamine chelates both FeIII and FeII. Implications for metal transport in plants
Nicolaus von Wirén,Sukhbinder Klair,Suhkibar Bansal,Jean-François Briat,Hicham Khodr,Takayuki Shioiri,Roger A. Leigh,Robert C. Hider +7 more
TL;DR: Capillary electrophoresis showed that in the presence of FeII and FeIII, NA preferentially chelates FeII, indicating that the FeIINA complex is kinetically stable under aerobic conditions and suggests that NA will have an important role in scavenging Fe and protecting the cell from oxidative damage.
Journal ArticleDOI
Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential--a workshop report and consensus statement.
Jon G Ayres,Paul J. A. Borm,Flemming R. Cassee,Vincent Castranova,Ken Donaldson,A.J. Ghio,Roy M. Harrison,Robert C. Hider,Frank J. Kelly,Ingeborg M. Kooter,Francelyne Marano,Robert L. Maynard,Ian Mudway,Andre E. Nel,Constantinos Sioutas,Steve Smith,Armelle Baeza-Squiban,Arthur K. Cho,Sean T Duggan,John R. Froines +19 more
TL;DR: In vitro test methods have an important role to play in the screening of toxicity in airborne particulate matter and nanoparticles and offer large cost advantages relative to human or animal inhalation studies and animal in vivo installation experiments.
Journal ArticleDOI
The Pseudomonas aeruginosa 4-Quinolone Signal Molecules HHQ and PQS Play Multifunctional Roles in Quorum Sensing and Iron Entrapment
Stephen P. Diggle,Sandra Matthijs,Victoria Wright,Matthew P. Fletcher,Siri Ram Chhabra,Iain L. Lamont,Xiaole Kong,Robert C. Hider,Pierre Cornelis,Miguel Cámara,Paul Williams +10 more
TL;DR: Biophysical analysis revealed that 2-alkyl-3-hydroxy-4-quinolones form complexes with iron(III) at physiological pH, and a secondary function for PQS in iron entrapment to facilitate siderophore-mediated iron delivery is revealed.