J
João Paulo Machado
Researcher at Universidade Federal de Viçosa
Publications - 29
Citations - 750
João Paulo Machado is an academic researcher from Universidade Federal de Viçosa. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 12, co-authored 26 publications receiving 587 citations. Previous affiliations of João Paulo Machado include National Institute of Standards and Technology.
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Journal ArticleDOI
NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism
Cristiane Zorzatto,João Paulo Machado,Kênia V. G. Lopes,Kelly J. T. Nascimento,Welison A. Pereira,Otávio J. B. Brustolini,Pedro A. B. Reis,Iara P. Calil,Michihito Deguchi,Gilberto Sachetto-Martins,Bianca C. Gouveia,Virgílio A. P. Loriato,Marcos A. C. Silva,Fabyano Fonseca e Silva,Anésia A. Santos,Joanne Chory,Elizabeth P. B. Fontes +16 more
TL;DR: LIMYB links immune receptor LRR-RLK activation to global translation suppression as an antiviral immunity strategy in plants, which results in protein synthesis inhibition, decreased viral messenger RNA association with polysome fractions and enhanced tolerance to begomovirus.
Journal ArticleDOI
Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus.
Claudine M. Carvalho,Anésia A. Santos,Silvana R. Pires,Carolina S. Rocha,Daniela I. Saraiva,João Paulo Machado,Eliciane Cevolani Mattos,Luciano Gomes Fietto,Elizabeth P. B. Fontes +8 more
TL;DR: Although the virulence function of the particular geminivirus NSP studied here overcomes this layer of defense in Arabidopsis, the NIK1-mediated signaling response may be involved in restricting the host range of other viruses.
Journal ArticleDOI
Immune Receptors and Co-receptors in Antiviral Innate Immunity in Plants.
TL;DR: A newly uncovered layer of antiviral defense that is specific to plant DNA viruses and relies on transmembrane receptor-mediated translational suppression for defense is discussed, integrating plant viruses into the co-evolutionary model of host-pathogen interactions, the zigzag model.
Journal ArticleDOI
The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling.
TL;DR: The NIK (NSP-interacting kinase)-mediated antiviral signaling pathway was identified as a virulence target of the begomovirus nuclear shuttle protein, and the ribosomal protein L10 (rpL10), a QM-like protein, as a downstream effector of the antiviral signalling was identified.
Journal ArticleDOI
Sustained NIK‐mediated antiviral signalling confers broad‐spectrum tolerance to begomoviruses in cultivated plants
Otávio J. B. Brustolini,João Paulo Machado,Jorge A. Condori-Apfata,Daniela Coco,Michihito Deguchi,Virgílio A. P. Loriato,Welison A. Pereira,Poliane Alfenas-Zerbini,Francisco Murilo Zerbini,Alice K. Inoue-Nagata,Alice K. Inoue-Nagata,Anésia A. Santos,Joanne Chory,Fabyano Fonseca e Silva,Elizabeth P. B. Fontes +14 more
TL;DR: It is observed that the mock-inoculated T474D-overexpressing lines showed a constitutively infected wild-type transcriptome, indicating that the activation of the NIK-mediated signalling pathway triggers a typical response to begomovirus infection.