O
Otávio J. B. Brustolini
Researcher at National Institute of Standards and Technology
Publications - 36
Citations - 1341
Otávio J. B. Brustolini is an academic researcher from National Institute of Standards and Technology. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 14, co-authored 31 publications receiving 859 citations. Previous affiliations of Otávio J. B. Brustolini include Universidade Federal de Viçosa.
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Journal ArticleDOI
Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil.
Carolina M. Voloch,Ronaldo da Silva Francisco,Luiz Gonzaga Paula de Almeida,Cynthia Chester Cardoso,Otávio J. B. Brustolini,Alexandra L. Gerber,Ana Paula de C Guimarães,Diana Mariani,Raissa Mirella da Costa,Orlando C. Ferreira,Thiago Silva Frauches,Claudia Maria Braga de Mello,Isabela de Carvalho Leitão,Rafael Mello Galliez,Débora S. Faffe,Terezinha M. P. P. Castineiras,Amilcar Tanuri,Ana Tereza Ribeiro de Vasconcelos +17 more
TL;DR: In this article, the emergence of novel SARS-CoV-2 lineages characterized by their phylogenetic and genetic distinction was reported, and several studies reported that these lineages can be classified into two groups.
Posted ContentDOI
Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil
Carolina M. Voloch,Ronaldo da Silva F,Luiz Gonzaga Paula de Almeida,Cynthia Chester Cardoso,Otávio J. B. Brustolini,Alexandra L. Gerber,Ana Paula de C Guimarães,Diana Mariani,Raissa Mirella da Costa,Orlando C. Ferreira,Covid Ufrj Workgroup,LNCC-Workgroup,Adriana Cony Cavalcanti,Thiago Silva Frauches,Claudia Maria Braga de Mello,Rafael Mello Galliez,Débora S. Faffe,Terezinha M. P. P. Castineiras,Amilcar Tanuri,Ana Tereza Ribeiro de Vasconcelos +19 more
TL;DR: In this article, the authors reported the sequencing of 180 new viral genomes obtained from different municipalities of the state of Rio de Janeiro from April to December 2020, and identified a novel lineage of SARS-CoV-2, originated from B.1.28 lineage, distinguished by five single-nucleotide variants (SNVs): C100U, C28253U, G28628u, G28975U, and C29754U.
Journal ArticleDOI
NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism
Cristiane Zorzatto,João Paulo Machado,Kênia V. G. Lopes,Kelly J. T. Nascimento,Welison A. Pereira,Otávio J. B. Brustolini,Pedro A. B. Reis,Iara P. Calil,Michihito Deguchi,Gilberto Sachetto-Martins,Bianca C. Gouveia,Virgílio A. P. Loriato,Marcos A. C. Silva,Fabyano Fonseca e Silva,Anésia A. Santos,Joanne Chory,Elizabeth P. B. Fontes +16 more
TL;DR: LIMYB links immune receptor LRR-RLK activation to global translation suppression as an antiviral immunity strategy in plants, which results in protein synthesis inhibition, decreased viral messenger RNA association with polysome fractions and enhanced tolerance to begomovirus.
Journal ArticleDOI
The tomato RLK superfamily: phylogeny and functional predictions about the role of the LRRII-RLK subfamily in antiviral defense.
Tetsu Sakamoto,Michihito Deguchi,Michihito Deguchi,Otávio J. B. Brustolini,Otávio J. B. Brustolini,Anésia A. Santos,Anésia A. Santos,Fabyano Fonseca e Silva,Elizabeth P. B. Fontes,Elizabeth P. B. Fontes +9 more
TL;DR: The tomato RLK superfamily is made-up of 647 proteins that form a monophyletic tree with the Arabidopsis RLKs and is divided into 58 subfamilies, which suggests that NIK-mediated antiviral signaling is also likely to operate in tomato, suggesting that tomato NIKs may be good targets for engineering resistance against tomato-infecting begomoviruses.
Journal ArticleDOI
The Endoplasmic Reticulum Binding Protein BiP Displays Dual Function in Modulating Cell Death Events
Humberto Henrique de Carvalho,Priscila Alves Silva,Giselle Camargo Mendes,Otávio J. B. Brustolini,Maiana R. Pimenta,Bianca C. Gouveia,Maria Anete S. Valente,Humberto J.O. Ramos,Juliana R.L. Soares-Ramos,Elizabeth P. B. Fontes +9 more
TL;DR: Data indicate that during the hypersensitive PCD, BiP positively regulates the NRP cell death signaling through a yet undefined mechanism that is activated by SA signaling and related to ER functioning, and BiP’s negative regulation of leaf senescence may be linked to its capacity to attenuate the UPR activation and NRPcell death signaling.