J
Jodi F. Hedges
Researcher at Montana State University
Publications - 39
Citations - 1175
Jodi F. Hedges is an academic researcher from Montana State University. The author has contributed to research in topics: T cell & Innate immune system. The author has an hindex of 18, co-authored 39 publications receiving 969 citations.
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Intrinsic Signal Amplification by Type-III CRISPR-Cas Systems Provides a Sequence-Specific Viral Diagnostic
Andrew Santiago-Frangos,Laina N. Hall,Anna Nemudraia,Artem Nemudryi,Pushya Krishna,Tanner Wiegand,Royce A. Wilkinson,Deann T. Snyder,Jodi F. Hedges,Mark A. Jutila,Matthew P. Taylor,Blake Wiedenheft +11 more
TL;DR: The type III CRISPR-Cas system is repurposed for sensitive and sequence specific detection of SARS-CoV-2 in an assay that can be performed in one hour or less and shows that amplified products of the Cas10-polymerase are detectable using colorimetric or fluorometric readouts.
Journal ArticleDOI
Oral delivery of oligomeric procyanidins in Apple Poly® enhances type I IFN responses in vivo
Deann T. Snyder,Amanda Robison,Sharon Kemoli,Emily Kimmel,Jeff Holderness,Mark A. Jutila,Jodi F. Hedges +6 more
TL;DR: It is confirmed that OPCs from two different sources significantly increased pSTAT1, whereas a monomeric form of procyanidin did not, and this suggests a unique, nonantioxidant aspect of O PCs that is broadly applicable to many disease settings.
Journal ArticleDOI
Adjuvant materials that enhance bovine γδ T cell responses.
TL;DR: This review focuses on recent results obtained using two adjuvant therapies for cattle that can be used to help mitigate infection using bovine γδ T cells, which are important lymphocytes of the innate immune system and of particular importance to ruminant immunological health.
Journal ArticleDOI
Titers, Prevalence, and Duration of SARS-CoV-2 Antibodies in a Local COVID-19 Outbreak and Following Vaccination
Jodi F. Hedges,Macy A Thompson,Deann T. Snyder,Amanda Robison,Matthew P. Taylor,Mark A. Jutila +5 more
TL;DR: It was found that antibody responses induced by vaccination were significantly higher than those induced by natural infection, suggesting that vaccination is still critical even for those naturally infected or diagnosed with COVID-19.
Posted ContentDOI
SARS-CoV-2 genomic surveillance identifies naturally occurring truncations of ORF7a that limit immune suppression
Artem Nemudryi,Anna Nemudraia,Tanner Wiegand,Joseph Nichols,Deann T. Snyder,Jodi F. Hedges,Calvin Cicha,Helen H Lee,Karl K Vanderwood,Diane Bimczok,Mark A. Jutila,Blake Wiedenheft +11 more
TL;DR: In this article, the C-terminal truncation of ORF7a has been shown to result in distinct changes in interferon stimulated gene expression, and these changes affect viral mechanisms responsible for suppressing the immune response.