Showing papers in "Vaccine in 2021"

TL;DR: A systematic search of the peer-reviewed English survey literature indexed in PubMed was done on 25 December 2020 as discussed by the authors to provide an up-to-date assessment of COVID-19 vaccination acceptance rates worldwide.

TL;DR: In this article, the authors evaluated the relationship between efficacy and in vitro neutralizing and binding antibodies of 7 vaccines for which sufficient data have been generated, and they found a robust correlation was seen between neutralizing titer and efficacy.

TL;DR: Ruiz et al. as discussed by the authors conducted an online survey of 804 U.S. English-speaking adults and found that the intention to vaccinate was highest for men, older people, individuals who identified as white and non-Hispanic, the affluent and college-educated, Democrats, those who were married or partnered, people with pre-existing medical conditions, and those vaccinated against influenza during the 2019-2020 flu season.

TL;DR: In this paper, the authors assess the attitudes towards the prospective COVID-19 vaccines among the general public in Jordan, Kuwait and other Arab countries, and assess the association between COVID19 vaccine acceptance and conspiracy beliefs.

TL;DR: In this paper, the authors used multinomial regression to identify factors associated with intention to delay or refuse to take COVID-19 vaccines in Portugal, finding that 56% would wait and 9% refuse.

TL;DR: In this article, the authors conducted a cross-sectional study to assess the attitude of healthcare workers toward COVID-19 vaccination and found that 36% of respondents were willing to take the vaccine as soon as it became available while 56% were not sure or would wait to review more data.

TL;DR: In this paper, the percentage of the population intending to vaccinate, unsure, or intending to refuse a COVID-19 vaccine when available was examined using large nationally representative samples.

TL;DR: In this article, a population-based, random telephone survey was performed during the peak of the third wave of COVID-19 outbreak (27/07/2020 to 27/08/2020) in Hong Kong.

TL;DR: In this paper, the authors evaluated 28 cases of immune-mediated disease flare or new disease onset within 28-days of SARS-CoV-2 vaccination at five large tertiary centres in countries with early vaccination adoption, three in Israel, one in UK, and one in USA.

TL;DR: The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and in vaccine reactogenicity as mentioned in this paper.

TL;DR: In this article, a scoping review was conducted in Medline®, Embase®, CINAHL®, and Scopus® and was reported in accordance with the PRISMA-SCr checklist.

TL;DR: In this paper, a nationally representative survey of 1476 adults in the UK between 12 and 18 December 2020, along with 5 focus groups conducted during the same period was used to investigate the role of trust, belief in conspiracy theories, and spread of misinformation through social media play in impacting vaccine hesitancy.

TL;DR: The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants in different continents is causing a major concern in human global health.

TL;DR: The current study systematically reviewed, summarized and meta-analyzed the clinical features of the vaccines in clinical trials to provide a better estimate of their efficacy, side effects and immunogenicity and found the adenovirus-vectored and mRNA-based vaccines showed the highest efficacy after first and second doses, respectively.

TL;DR: In this article, the authors reported six cases of myocarditis, which occurred shortly after BNT162b2 vaccination, and they were identified upon presentation to the emergency department with symptoms of chest pain/discomfort.

TL;DR: Vaccination with mRNA-1273 resulted in significant immune responses to SARS-CoV-2 in participants 18 years and older, with an acceptable safety profile, confirming the safety and immunogenicity of 50 and 100 ug mRNA- 1273 given as a 2 dose-regimen.

TL;DR: In this article, the willingness of people in Japan to be vaccinated or not be vaccinated and the reasons for either decision was explored and a questionnaire survey was administered to evaluate their willingness to get vaccinated by gender, age group, place of living, and underlying illness history.

TL;DR: In this paper, the acceptance of COVID-19 vaccine in Japan was investigated and several psychological factors, such as perceived effectiveness of the vaccine and willingness to protect others by getting oneself vaccinated, were associated with vaccine acceptance.

TL;DR: A review of lipid nanoparticles for various applications, ranging from cancer nanomedicines to COVID-19 vaccines, is presented in this article, focusing on the innovations that have obtained regulatory approval or that are in clinical trials.

TL;DR: In this paper, the authors conducted cross-sectional online surveys to investigate COVID-19 vaccine acceptance across nine Low and Middle-Income Countries (LMICs; N = 10,183), assuming vaccine effectiveness at 90% and 95%.

TL;DR: In this article, the authors provide an overview of the results from pre-clinical studies in animal models as well as clinical studies in humans that assessed the efficacy of SARS-CoV-2 mRNA vaccines, with a primary focus on adaptive immune responses post vaccination.

TL;DR: A synthesis of the major challenges and opportunities associated with a future COVID-19 vaccination campaign and empirically-informed recommendations to advance public understanding of, access to, and acceptance of vaccines that protect against SARS-CoV-2 are presented.

TL;DR: The Brighton Collaboration case definition of Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A) was developed by topic experts in the context of active development of vaccines for SARS-CoV-2 as discussed by the authors.

TL;DR: A review of the current state-of-the-art of mRNA vaccines can be found in this article, focusing on the challenges and bottlenecks of manufacturing that need to be addressed to turn this new vaccination technology into an effective, fast and cost-effective response to emerging health crises.

TL;DR: The meta-analysis shows nearly half of young COVID-19 cases were asymptomatic and half were infants, highlighting the need for ongoing surveillance to better understand the epidemiology, clinical pattern, and transmission of CO VID-19 to develop effective preventive strategies against COVID -19 disease in young paediatric population.

TL;DR: To maximize COVID-19 vaccine uptake, health authorities should promote vaccine effectiveness; pro-actively communicate the absence or presence of vaccine side effects; and ensure rapid and wide media communication about local vaccine coverage.

TL;DR: The main influenza complications and societal impacts beyond the classical respiratory symptoms of the disease are outlined.

TL;DR: In this paper, a cross-sectional study was conducted by distributing an online survey targeted toward Jordan inhabitants who received any COVID-19 vaccines, and data were statistically analyzed and certain machine learning (ML) tools, including multilayer perceptron (MLP), eXtreme gradient boosting (XGBoost), random forest (RF), and K-star were used to predict the severity of side effects.

TL;DR: In this analysis, myopericarditis was most commonly reported after smallpox vaccine, and less commonly after other vaccines.