J
Joel N. Hirschhorn
Researcher at Stanford University
Publications - 4
Citations - 271
Joel N. Hirschhorn is an academic researcher from Stanford University. The author has contributed to research in topics: Genotype & Gene expression. The author has an hindex of 1, co-authored 4 publications receiving 248 citations.
Papers
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Journal ArticleDOI
What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations
Orestis A. Panagiotou,John P. A. Ioannidis,John P. A. Ioannidis,John P. A. Ioannidis,Joel N. Hirschhorn,Gonçalo R. Abecasis,Timothy M. Frayling,Mark I. McCarthy,Cecilia M. Lindgren,Terri H. Beaty,Nicholas Eriksson,Constantin Polychronakos,Sekar Kathirensan,Robert M. Plenge,Richard A. Spritz,Haydeh Payami,Eden R. Martin,Jeffery M. Vance,Wen Hui Su,Yu Sun Chang,Jin Xin Bei,Yi Xin Zeng,Guillaume Paré,Stephen V. Faraone,Benjamine Neale,Richard Anney,Bryan J. Traynor,André Scherag,Johannes Hebebrand,Anke Hinney,Philippe Froguel,David Meyre,Stephen J. Chanock,Wang Kesheng +33 more
TL;DR: A substantial proportion, but not all, of the associations with borderline genome-wide significance represent replicable, possibly genuine associations, which suggests a possible relaxation in the current GWS threshold.
Patent
Gene expression associated with glucose tolerance
Cecilia M. Lindgren,Joel N. Hirschhorn,Pablo Tamayo,Mark J. Daly,Eric S. Lander,David Altshuler +5 more
Brief Genetics Report The Kruppel-Like Factor 11 (KLF11) Q62R Polymorphism Is Not Associated With Type 2 Diabetes in 8,676 People
Jose C. Florez,Richa Saxena,Wendy Winckler,Peter Almgren,Tiinamaija Tuomi,Daniel Gaudet,Kristin G. Ardlie,Mark J. Daly,David Altshuler,Joel N. Hirschhorn,Leif Groop +10 more
TL;DR: In this article, the authors examined the impact of KLF11 variants on common type 2 diabe- tes in several family-based and case-control samples of northern-European ancestry, totaling 8,676 individuals.