H
Haydeh Payami
Researcher at University of Alabama at Birmingham
Publications - 128
Citations - 13934
Haydeh Payami is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Age of onset & Population. The author has an hindex of 56, co-authored 125 publications receiving 11942 citations. Previous affiliations of Haydeh Payami include Emory University & University of California, Berkeley.
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Journal ArticleDOI
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Mike A. Nalls,Nathan Pankratz,Christina M. Lill,Chuong B. Do,Dena G. Hernandez,Dena G. Hernandez,Mohamad Saad,Mohamad Saad,Mohamad Saad,Anita L. DeStefano,Anita L. DeStefano,Eleanna Kara,Jose Bras,Manu Sharma,Claudia Schulte,Margaux F. Keller,Sampath Arepalli,Christopher Letson,Connor Edsall,Hreinn Stefansson,Xinmin Liu,Hannah A. Pliner,Joseph H. Lee,Rong Cheng,M. Arfan Ikram,John P. A. Ioannidis,Georgios M. Hadjigeorgiou,Joshua C. Bis,Maria Martinez,Maria Martinez,Joel S. Perlmutter,Alison Goate,Karen Marder,Brian K. Fiske,Margaret Sutherland,Georgia Xiromerisiou,Richard H. Myers,Lorraine N. Clark,Kari Stefansson,John Hardy,Peter Heutink,Honglei Chen,Nicholas W. Wood,Henry Houlden,Haydeh Payami,Alexis Brice,Alexis Brice,William K. Scott,Thomas Gasser,Lars Bertram,Nicholas Eriksson,Tatiana Foroud,Andrew B. Singleton +52 more
TL;DR: This article conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls.
Journal ArticleDOI
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Taye H. Hamza,Cyrus P. Zabetian,Cyrus P. Zabetian,Albert Tenesa,Alain Laederach,Jennifer S. Montimurro,Dora Yearout,Dora Yearout,Dora Yearout,Denise M. Kay,Kimberly F. Doheny,Justin Paschall,Elizabeth W. Pugh,Victoria I. Kusel,Randall V. Collura,John W. Roberts,Alida Griffith,Ali Samii,Ali Samii,William K. Scott,John G. Nutt,Stewart A. Factor,Haydeh Payami,Haydeh Payami +23 more
TL;DR: The genome-wide association study of 2,000 individuals with Parkinson's disease and unaffected controls confirmed associations with SNCA and MAPT and detected a new association with the HLA region, which was uniform across all genetic and environmental risk strata and was strong in sporadic and late-onset disease.
Journal ArticleDOI
Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome
Erin M. Hill-Burns,Justine W. Debelius,James T. Morton,William T. Wissemann,Matthew R. Lewis,Zachary D. Wallen,Shyamal D. Peddada,Stewart A. Factor,Eric Molho,Cyrus P. Zabetian,Rob Knight,Haydeh Payami +11 more
TL;DR: There is mounting evidence for a connection between the gut and Parkinson's disease (PD).
Journal ArticleDOI
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene database.
Christina M. Lill,Johannes T. Roehr,Johannes T. Roehr,Matthew B. McQueen,Fotini K. Kavvoura,Fotini K. Kavvoura,Fotini K. Kavvoura,Sachin Bagade,Brit-Maren M. Schjeide,Leif M. Schjeide,Esther Meissner,Ute Zauft,Nicole C. Allen,Tian-Jing Liu,Marcel Schilling,Marcel Schilling,Kari J. Anderson,Gary W. Beecham,Daniela Berg,Daniela Berg,Joanna M. Biernacka,Alexis Brice,Anita L. DeStefano,Chuong B. Do,Nicholas Eriksson,Stewart A. Factor,Matthew J. Farrer,Tatiana Foroud,Thomas Gasser,Thomas Gasser,Taye H. Hamza,John Hardy,Peter Heutink,Erin M. Hill-Burns,Christine Klein,Jeanne C. Latourelle,Demetrius M. Maraganore,Eden R. Martin,Maria Martinez,Maria Martinez,Richard H. Myers,Mike A. Nalls,Nathan Pankratz,Haydeh Payami,Wataru Satake,William K. Scott,Manu Sharma,Manu Sharma,Andrew B. Singleton,Kari Stefansson,Tatsushi Toda,Joyce Y. Tung,Jeffery M. Vance,Nicholas W. Wood,Cyrus P. Zabetian,Peter Young,Rudolph E. Tanzi,Muin J. Khoury,Frauke Zipp,Hans Lehrach,John P. A. Ioannidis,Lars Bertram,Lars Bertram +62 more
TL;DR: This study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies.
Journal ArticleDOI
Identification of a Novel LRRK2 Mutation Linked to Autosomal Dominant Parkinsonism: Evidence of a Common Founder across European Populations
Jennifer M. Kachergus,Ignacio F. Mata,Mary M. Hulihan,Julie P. Taylor,Sarah Lincoln,Jan O. Aasly,J. Mark Gibson,Owen A. Ross,Timothy Lynch,Timothy Lynch,Joseph Wiley,Joseph Wiley,Haydeh Payami,John G. Nutt,Demetrius M. Maraganore,Krzysztof Czyzewski,Maria Styczyńska,Zbigniew K. Wszolek,Matthew J. Farrer,Mathias Toft +19 more
TL;DR: It is demonstrated that LRRK2 G2019S accounts for parkinsonism in several families within Europe and North America, highlighting the fact that a proportion of clinically typical, late-onset PD cases have a genetic basis.