C
Constantin Polychronakos
Researcher at McGill University Health Centre
Publications - 221
Citations - 17054
Constantin Polychronakos is an academic researcher from McGill University Health Centre. The author has contributed to research in topics: Allele & Genome-wide association study. The author has an hindex of 59, co-authored 214 publications receiving 15844 citations. Previous affiliations of Constantin Polychronakos include Jewish General Hospital & Université de Montréal.
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Journal ArticleDOI
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek,Ghislain Rocheleau,Johan Rung,Christian Dina,Lishuang Shen,David Serre,Philippe Boutin,Daniel Vincent,Alexandre Belisle,Samy Hadjadj,Beverley Balkau,Barbara Heude,Guillaume Charpentier,Thomas J. Hudson,Thomas J. Hudson,Alexandre Montpetit,Alexey V. Pshezhetsky,Marc Prentki,Barry I. Posner,David J. Balding,David Meyre,Constantin Polychronakos,Philippe Froguel,Philippe Froguel +23 more
TL;DR: Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
Journal ArticleDOI
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Petros Vafiadis,Simon T. Bennett,John A. Todd,Joseph H. Nadeau,Rosemarie Grabs,Cynthia G. Goodyer,Saman Wickramasinghe,Eleanor Colle,Constantin Polychronakos +8 more
TL;DR: Higher levels of thymic INS expression are proposed, facilitating immune tolerance induction, as a mechanism for the dominant protective effect of class III alleles.
Journal ArticleDOI
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
David Meyre,Jérôme Delplanque,Jean-Claude Chèvre,Cécile Lecoeur,Stéphane Lobbens,Sophie Gallina,Emmanuelle Durand,Vincent Vatin,Franck Degraeve,Christine Proença,Stefan Gaget,Antje Körner,Peter Kovacs,Wieland Kiess,Jean Tichet,Michel Marre,Anna-Liisa Hartikainen,Fritz F. Horber,Natascha Potoczna,Serge Hercberg,Claire Levy-Marchal,Claire Levy-Marchal,François Pattou,Barbara Heude,Maithé Tauber,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Alexandra I. F. Blakemore,Alexandre Montpetit,Constantin Polychronakos,Jacques Weill,Lachlan J. M. Coin,Julian E. Asher,Paul Elliott,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Sophie Visvikis-Siest,Beverley Balkau,Robert Sladek,David J. Balding,Andrew Walley,Christian Dina,Philippe Froguel,Philippe Froguel +44 more
TL;DR: In addition to FTO and MC4R, genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls detected significant association of obesity with three new risk loci in NPC1, near MAF and near PTER.
Journal ArticleDOI
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
Hakon Hakonarson,Struan F.A. Grant,Jonathan P. Bradfield,Luc Marchand,Cecilia E. Kim,Joseph T. Glessner,Rosemarie Grabs,Tracy Casalunovo,Shayne Taback,Edward Frackelton,Margaret L. Lawson,Luke J. Robinson,Robert Skraban,Yang Lu,Rosetta M. Chiavacci,Charles A. Stanley,Susan E. Kirsch,Eric F. Rappaport,Jordan S. Orange,Dimitri S. Monos,Dimitri S. Monos,Marcella Devoto,Hui-Qi Qu,Constantin Polychronakos +23 more
TL;DR: It is found that T1D was significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that contains KIAA0350, the gene product of which is predicted to be a sugar-binding, C-type lectin.
Journal ArticleDOI
Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease
David Neil Cooper,Michael Krawczak,Constantin Polychronakos,Chris Tyler-Smith,Hildegard Kehrer-Sawatzki +4 more
TL;DR: The evidence for reduced penetrance being a widespread phenomenon in human genetics is summarized and some of the molecular mechanisms that may help to explain this enigmatic characteristic of human inherited disease are explored.