Johan F. Koster

TL;DR: It is reported that stimulated polymorphonuclear leukocytes mobilize iron from human and horse ferritin, but not from human transferrin, and it is proposed that this reaction may potentiate the formation of the OH.

TL;DR: The cytokine tumor necrosis factor (TNF) alpha was found to stimulate the p38 mitogen activated protein (MAP) kinase signalling cascade in human umbilical vein endothelial cells, and VCAM-1 mRNA accumulation induced by TNFalpha was not affected by SB203580, suggesting that the p37 MAP kinase signaling cascade regulates the endothelial expression of VCam-1 at the post-transcriptional level.

TL;DR: The O2(-)-produced by xanthine oxidase, or granulocytes, will be converted by 'free' iron into much more highly toxic oxygen species such as hydroxyl radicals (OH.), exacerbating the tissue damage.

TL;DR: Evidence is presented that oxygen free radicals are involved in the pathogenesis of rheumatoid arthritis (RA), and superoxide is able to release iron from ferritin, providing a suitable source of iron, for the formation of hydroxyl radicals.

TL;DR: The findings suggest that the fluorescent chromolipids formed by lipid peroxidation are not derived from malonaldehyde, but are formed from 4-hydroxynonenal or similar reactive aldehydes via a NADPH and/or ADP-iron-catalysed reaction with phosphatidylethanolamine and phosphatodylserine contained in the membrane.