J
Johan Kreuger
Researcher at Uppsala University
Publications - 60
Citations - 7136
Johan Kreuger is an academic researcher from Uppsala University. The author has contributed to research in topics: Heparan sulfate & Angiogenesis. The author has an hindex of 28, co-authored 56 publications receiving 6545 citations. Previous affiliations of Johan Kreuger include Science for Life Laboratory.
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Journal ArticleDOI
VEGF receptor signalling - in control of vascular function.
TL;DR: Recent insights have shed light onto VEGFR signal transduction and the interplay between different V EGFRs and VEGF co-receptors in development, adult physiology and disease.
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Interactions between heparan sulfate and proteins: the concept of specificity
TL;DR: This review summarizes recent biochemical and genetic information that sheds new light on the nature of HS–protein binding that appears to depend more on the overall organization of HS domains than on their fine structure.
Journal ArticleDOI
Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis.
Lars Jakobsson,Johan Kreuger,Katarina Holmborn,Lars Lundin,Inger Eriksson,Lena Kjellén,Lena Claesson-Welsh +6 more
TL;DR: It is shown, by using chimeric cultures of embryonic stem cells defective in either HS production or VEGFR-2 synthesis, that VEGF signaling in endothelial cells is fully supported by HS expressed in trans by adjacent perivascular smooth muscle cells.
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Inflammation-related genes up-regulated in schizophrenia brains
TL;DR: The results indicate alterations of inflammation-related pathways in schizophrenia, and the observation in oligodendrocyte cells suggests that alterations in inflammatory-related genes may have consequences for myelination.
Journal ArticleDOI
Heparan sulfate biosynthesis: regulation and variability.
Johan Kreuger,Lena Kjellén +1 more
TL;DR: This review provides an introduction to the current understanding of HS biosynthesis and its regulation, and identifies research areas where more knowledge is needed to better understand how the HS biosynthetic machinery works.