Johanna A. Smith

TL;DR: The data indicate that a subset of human breast cancer patients with a loss of stromal Cav-1 show profound metabolic changes in the tumor microenvironment, and this subgroup of patients may benefit therapeutically from potent inhibitors targeting glycolysis, autophagy and/or mitochondrial activity.

TL;DR: This review gives a brief summary of the accomplishments in the field of DNA repair and retroviral integration and the opportunities that this area of science provides with regards to the elucidation of repair mechanisms, in the context of Retroviral infection.

TL;DR: This review outlines the current knowledge of the mechanism of integration site selection by retroviruses in vitro, in cultured cells, and in vivo; the outcome of several of the more recent gene therapy trials, which employed these vectors; and the efforts of several laboratories to develop vectors that integrate at predetermined sites in the human genome.

TL;DR: Transient overexpression of TIHPLE alters integration site selection by an HIV-1-based vector and decreases the number of integration events that occur in genes and provides a novel approach to address the problem of the tendency of retroviral vectors to integrate at undesirable sites of the human genome.

TL;DR: It is proposed that the Tat-induced DNA repair deficiencies may play a significant role in the development of AIDS-associated cancer.