R
René Daniel
Researcher at Thomas Jefferson University
Publications - 43
Citations - 2188
René Daniel is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: DNA repair & Virus Integration. The author has an hindex of 22, co-authored 42 publications receiving 2047 citations. Previous affiliations of René Daniel include Fox Chase Cancer Center.
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Journal ArticleDOI
A role for DNA-PK in retroviral DNA integration.
TL;DR: It is shown that DNA-dependent protein kinase (DNA-PK), a host cell protein, also participates in the reaction, suggesting that completion of the integration process requires the DNA-PK-mediated repair pathway.
Journal Article
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis (Journal of Biological Chemistry (2008) 283, (6572-6583))
TL;DR: It is shown that ATR is specifically activated during cisplatin treatment and co-localizes with H2AX, forming nuclear foci at the site of DNA damage, suggesting an important role for the DNA damage response mediated by ATR-Chk2 in p53 activation and renal cell apoptosis during cisPlatin nephrotoxicity.
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ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis
TL;DR: In this article, the authors demonstrate an early DNA damage response during cisplatin treatment of renal cells and tissues, and demonstrate a critical role for ATR, but not ATM (ataxia telangiectasia mutated) or DNA-PK (DNA-dependent protein kinase), in the activation and apoptosis of kidney cells.
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The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity
Salvatore Cortellino,David P. Turner,Valeria Masciullo,Filippo Schepis,Domenico Albino,René Daniel,Anna Marie Skalka,Neal J. Meropol,Christophe Alberti,Lionel Larue,Alfonso Bellacosa +10 more
TL;DR: MED1 has an additional role in DNA damage response to antitumor agents and is associated with integrity of the MMR system, which may impair cell cycle arrest and apoptosis induced by DNA damage.
Journal ArticleDOI
Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway.
René Daniel,James G. Greger,Richard A. Katz,Konstantin Taganov,Xiaoyun Wu,John C. Kappes,Anna Marie Skalka +6 more
TL;DR: Evidence is provided that NHEJ proteins are required for stable transduction by human immunodeficiency type 1 (HIV-1)-based vectors and that cells deficient in ligase IV are killed by infection with an integrase-competent but not anIntegrase-deficient HIV-1 vector.