J
Johanna van der Ven-Jongekrijg
Researcher at Radboud University Nijmegen Medical Centre
Publications - 9
Citations - 373
Johanna van der Ven-Jongekrijg is an academic researcher from Radboud University Nijmegen Medical Centre. The author has contributed to research in topics: Tumor necrosis factor alpha & Septic shock. The author has an hindex of 8, co-authored 9 publications receiving 351 citations. Previous affiliations of Johanna van der Ven-Jongekrijg include Radboud University Nijmegen.
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Journal ArticleDOI
The Pattern of Interleukin-1β (IL-1β) and Its Modulating Agents IL-1 Receptor Antagonist and IL-1 Soluble Receptor Type II in Acute Meningococcal Infections
Marcel van Deuren,Johanna van der Ven-Jongekrijg,Edouard Vannier,Roelof van Dalen,G.J. Pesman,A.K.M. Bartelink,Charles A. Dinarello,Jos W. M. van der Meer +7 more
TL;DR: During the early stage of meningococcal infections IL-1Ra modulatesIL-1 activity, whereas during recovery IL-2sRII may be more important, which suggests different modulation of IL- 1beta activity in the subarachnoid space and the plasma compartment.
Journal ArticleDOI
Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome
Heleen D. de Koning,Joost Schalkwijk,Johanna van der Ven-Jongekrijg,Monique Stoffels,Jos W. M. van der Meer,Anna Simon +5 more
TL;DR: The data demonstrate that IL-1β plays a pivotal role in this disease, and monthly 150 mg canakinumab injection was an effective and well-tolerated treatment for Schnitzler's syndrome.
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Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release.
Mihai G. Netea,Bart Jan Kullberg,Liesbeth E. H. Jacobs,Trees J.G. Verver-Jansen,Johanna van der Ven-Jongekrijg,Jochem M. D. Galama,Anton F. H. Stalenhoef,Charles A. Dinarello,Jos W. M. van der Meer +8 more
TL;DR: It is demonstrated that Chlamydia pneumoniae is an important stimulus for IFN-gamma synthesis, and this production depends on release of endogenous IL-18, IL-12, and IL-1, but not of TNF, which may contribute to its proatherogenic effects.
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Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity.
Anna Simon,Bart Jan Kullberg,Brian Tripet,Otto C. Boerman,Patrick L.J.M. Zeeuwen,Johanna van der Ven-Jongekrijg,Paul E. Verweij,Joost Schalkwijk,Robert S. Hodges,Jos W. M. van der Meer,Mihai G. Netea +10 more
TL;DR: The expression of DLD mRNA in several human tissues, particularly in the skin, consistent with its putative role as a defensin against invading microorganisms is shown, the first indication of an endogenous human peptide with specific antifungal activity.
Journal ArticleDOI
Persistence of Salmonellae in Blood and Bone Marrow: Randomized Controlled Trial Comparing Ciprofloxacin and Chloramphenicol Treatments against Enteric Fever
M. Hussein Gasem,Monique Keuter,Wil M. V. Dolmans,Johanna van der Ven-Jongekrijg,R. Djokomoeljanto,Jos W. M. van der Meer +5 more
TL;DR: Although ciprofloxacin was more effective in the elimination of Salmonellaenterica serovars Typhi and Paratyphi A from bone marrow than chloramphenicol, there was still an impressive persistence of Salbornella in the bone marrow culture.