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Johannes Huebner

Researcher at Ludwig Maximilian University of Munich

Publications -  97
Citations -  4343

Johannes Huebner is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Enterococcus faecalis & Enterococcus faecium. The author has an hindex of 36, co-authored 91 publications receiving 3962 citations. Previous affiliations of Johannes Huebner include University of Freiburg & University Medical Center.

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Coagulase-Negative Staphylococci: Role as Pathogens

TL;DR: Coagulase-negative staphylococci are by far the most common cause of bacteremia related to indwelling devices and their important role as pathogens and their increasing incidence have been recognized and studied in recent years.
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Alanine esters of enterococcal lipoteichoic acid play a role in biofilm formation and resistance to antimicrobial peptides.

TL;DR: The data suggest that the absence of d-alanine in LTA plays a role in environmental interactions, probably by modulating the net negative charge of the bacterial cell surface, and therefore it may be involved in the pathogenesis of this organism.
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Pathogenesis and immunity in enterococcal infections.

TL;DR: Several proteins and carbohydrate- or glycoconjugates that have been identified as putative virulence factors involved in the pathogenesis of enterococcal infections and may be used as targets for alternative therapies are summarized.
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Cystic fibrosis sputum DNA has NETosis characteristics and neutrophil extracellular trap release is regulated by macrophage migration-inhibitory factor.

TL;DR: It is suggested that targeting MIF by small molecular inhibitors might reduce the presence of extracellular DNA and serve as an adjunct to the use of antimicrobial drugs that could ultimately reduce bacterial fitness in the lungs during the later stages of CF disease.
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Enterococcal infections: host response, therapeutic, and prophylactic possibilities.

TL;DR: The development of an enterococcal vaccine based on capsular polysaccharides may improve the ability to prevent and treat these infections and the search for alternative treatment and preventive options is important.