Pathogenesis and immunity in enterococcal infections.
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TLDR
Several proteins and carbohydrate- or glycoconjugates that have been identified as putative virulence factors involved in the pathogenesis of enterococcal infections and may be used as targets for alternative therapies are summarized.About:
This article is published in Clinical Microbiology and Infection.The article was published on 2010-06-01 and is currently open access. It has received 218 citations till now. The article focuses on the topics: Enterococcus faecium & Enterococcus faecalis.read more
Citations
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Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry: a Fundamental Shift in the Routine Practice of Clinical Microbiology
TL;DR: This review summarizes the current position of MALDI-TOF MS in clinical research and in diagnostic clinical microbiology laboratories and serves as a primer to examine the “nuts and bolts” of MalDI-toF MS, highlighting research associated with sample preparation, spectral analysis, and accuracy.
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Intrinsic and acquired resistance mechanisms in enterococcus
TL;DR: The mechanisms underlying antibiotic resistance in enterococci may be intrinsic to the species or acquired through mutation of intrinsic genes or horizontal exchange of genetic material encoding resistance determinants.
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Metagenomic Analysis of the Stool Microbiome in Patients Receiving Allogeneic Stem Cell Transplantation: Loss of Diversity Is Associated with Use of Systemic Antibiotics and More Pronounced in Gastrointestinal Graft-versus-Host Disease
Ernst Holler,Peter Butzhammer,Karin Schmid,Christian Hundsrucker,Josef Koestler,Katrin Peter,Wentao Zhu,Daniela Sporrer,Thomas Hehlgans,Marina Kreutz,Barbara Holler,Daniel Wolff,Matthias Edinger,Reinhard Andreesen,John E. Levine,James L.M. Ferrara,André Gessner,Rainer Spang,Peter J. Oefner +18 more
TL;DR: Major microbiome shifts in the course of allogeneic SCT that occur in the period of antibiotic treatment but are more prominent in association with GI GVHD are revealed.
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The Enterococcus: a Model of Adaptability to Its Environment
TL;DR: A remarkably plastic genome allows these two species to readily acquire resistance to further antibiotics, such as high-level aminoglycoside resistance, high- level ampicillin resistance, and vancomycin resistance, either through mutation or by horizontal transfer of genetic elements conferring resistance determinants.
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Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria.
Daniel Dar,Maya Shamir,J. R. Mellin,J. R. Mellin,J. R. Mellin,Mikael Koutero,Mikael Koutero,Mikael Koutero,Noam Stern-Ginossar,Pascale Cossart,Pascale Cossart,Pascale Cossart,Rotem Sorek +12 more
TL;DR: It is found that numerous antibiotics resistance genes, in both pathogenic bacteria and in the human microbiome, are regulated via termination-based ribo-regulators that allow read-through when the antibiotic is present in the cell.
References
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A Continuum of Anionic Charge: Structures and Functions of d-Alanyl-Teichoic Acids in Gram-Positive Bacteria
TL;DR: The structures and functions of d- alanyl-TAs, the d-alanylation system encoded by the dlt operon, and the roles of TAs in cell growth are addressed.
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The Enterococcal Surface Protein, Esp, Is Involved in Enterococcus faecalis Biofilm Formation
Alejandro Toledo-Arana,Jaione Valle,Cristina Solano,Marı́a Jesús Arrizubieta,Carme Cucarella,Marta Lamata,Beatriz Amorena,José Leiva,José R. Penadés,Iñigo Lasa +9 more
TL;DR: It is demonstrated that biofilm formation capacity is widespread among clinical E. faecalis isolates, the biofilmformation capacity is restricted to the E.Faecalis strains harboringesp, and Esp promotes primary attachment and biofilm Formation of E. Faecalis on abiotic surfaces.
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A simple model host for identifying Gram-positive virulence factors
Danielle A. Garsin,Costi D. Sifri,Eleftherios Mylonakis,Xiang Qin,Kavindra V. Singh,Barbara E. Murray,Stephen B. Calderwood,Frederick M. Ausubel +7 more
TL;DR: The use of the nematode Caenorhabditis elegans is demonstrated as a facile and inexpensive model host for several Gram-positive human bacterial pathogens and an E. faecalis virulence factor, ScrB, which is relevant to mammalian pathogenesis is exploited.
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Endocarditis and biofilm-associated pili of Enterococcus faecalis
Sreedhar R. Nallapareddy,Kavindra V. Singh,Jouko Sillanpää,Danielle A. Garsin,Magnus Höök,Stanley L. Erlandsen,Barbara E. Murray +6 more
TL;DR: It is demonstrated that both the ebp (encoding endocarditis and biofilm-associated pili) operon and srtC are important for biofilm production of E. faecalis strain OG1RF and surface pili may be a useful immunotarget for studies aimed at prevention and/or treatment of this pathogen.