J
Johannes van de Nes
Researcher at Ruhr University Bochum
Publications - 31
Citations - 1096
Johannes van de Nes is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Melanoma & GNAQ. The author has an hindex of 15, co-authored 31 publications receiving 910 citations. Previous affiliations of Johannes van de Nes include University of Duisburg-Essen.
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Journal ArticleDOI
Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3.
Marcel Martin,Marcel Martin,Lars Maßhöfer,Petra Temming,Sven Rahmann,Claudia H D Metz,Norbert Bornfeld,Johannes van de Nes,Ludger Klein-Hitpass,Alan G. Hinnebusch,Bernhard Horsthemke,Dietmar R. Lohmann,Michael Zeschnigk +12 more
TL;DR: Using exome sequencing, recurrent somatic mutations in EIF1AX and SF3B1 are identified occurring in uveal melanomas with disomy 3, which rarely metastasize and are associated with poor prognosis.
Journal ArticleDOI
Genetic and clinico-pathologic analysis of metastatic uveal melanoma.
Klaus G. Griewank,Johannes van de Nes,Bastian Schilling,Iris Moll,Antje Sucker,Hojabr Kakavand,Lauren E. Haydu,Marina Asher,Lisa Zimmer,Uwe Hillen,John F. Thompson,Richard A. Scolyer,Dirk Schadendorf,Rajmohan Murali +13 more
TL;DR: The survival data, combined with the predominance of GNA11 mutations in metastases, raises the possibility that GNA 11-mutant tumors may be associated with a higher risk of metastasis and poorer prognosis than GNAQ-mutants tumors.
Journal ArticleDOI
Comparing the Prognostic Value of BAP1 Mutation Pattern, Chromosome 3 Status, and BAP1 Immunohistochemistry in Uveal Melanoma.
Johannes van de Nes,Jasmin Nelles,Stefan Horst Kreis,Claudia H D Metz,Thomas Hager,Dietmar R. Lohmann,Michael Zeschnigk +6 more
TL;DR: BAP1 protein staining is favorable over BAP1 mutation screening by Sanger sequencing for prognostic testing of UM patients, and a highly significant association between B AP1protein staining and patients’ survival is revealed.
Journal ArticleDOI
SF3B1 and BAP1 mutations in blue nevus-like melanoma
Klaus G. Griewank,Hansgeorg Müller,Louise Jackett,Louise Jackett,Michael Emberger,Inga Möller,Johannes van de Nes,Johannes van de Nes,Lisa Zimmer,Elisabeth Livingstone,Thomas Wiesner,Simone L. Scholz,Ioana Cosgarea,Antje Sucker,Tobias Schimming,Uwe Hillen,Bastian Schilling,Bastian Schilling,Annette Paschen,Henning Reis,Thomas Mentzel,Heinz Kutzner,Arno Rütten,Rajmohan Murali,Richard A. Scolyer,Richard A. Scolyer,Dirk Schadendorf +26 more
TL;DR: The findings suggest that the genetic profile of coexistent GNAQ or GNA11 mutations with BAP1 or SF3B1 mutations can aid the histopathological diagnosis of blue nevus-like melanoma and distinguish blue neVus- like melanoma from conventional epidermal-derived melanomas.
Journal ArticleDOI
Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system
Johannes van de Nes,Marco Gessi,Antje Sucker,Inga Möller,Mathias Stiller,Susanne Horn,Simone L. Scholz,Carina Pischler,Nadine Stadtler,Bastian Schilling,Lisa Zimmer,Uwe Hillen,Richard A. Scolyer,Michael E. Buckland,Michael E. Buckland,Libero Lauriola,Torsten Pietsch,Andreas Waha,Dirk Schadendorf,Rajmohan Murali,Klaus G. Griewank +20 more
TL;DR: It is shown that while MT-CNS do have GNAQ or GNA11 mutations, they rarely harbor other recurrent mutations found in uveal or cutaneous melanomas.