J
Johannes Voegel
Researcher at Collège de France
Publications - 53
Citations - 4088
Johannes Voegel is an academic researcher from Collège de France. The author has contributed to research in topics: Rosacea & Nuclear receptor. The author has an hindex of 21, co-authored 53 publications receiving 3715 citations. Previous affiliations of Johannes Voegel include French Institute of Health and Medical Research & Bristol-Myers Squibb.
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Journal ArticleDOI
TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
TL;DR: The cloning of the 160 kDa human nuclear protein TIF2 is reported, which exhibits all properties expected for a mediator of AF‐2 and exhibits partial sequence homology with the recently isolated steroid receptor coactivator SRC‐1, indicating the existence of a novel gene family of nuclear receptor transcriptional mediators.
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The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
Johannes Voegel,Matthias J.S. Heine,Marc Tini,Valérie Vivat,Pierre Chambon,Hinrich Gronemeyer +5 more
TL;DR: TIF2 exhibited the characteristics expected for a bona fide NR coactivator, in both mammalian and yeast cells, and a peptide encompassing the TIF2 NID inhibited the ligand‐induced AF‐2 activity of several NRs, indicating that NR AF‐ 2 activity is either mediated by endogenous Tif2 or by coactivators recognizing a similar surface on NR holo‐LBDs.
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Activation Function 2 in the Human Androgen Receptor Ligand Binding Domain Mediates Interdomain Communication with the NH2-terminal Domain
TL;DR: Evidence is provided that activation function 2 in the androgen receptor serves as the contact site for theandrogen dependent NH2- and carboxyl-terminal interaction of the androgens receptor and only weakly interacts with p160 coactivators in an LXXLL-dependent manner.
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Clinical, Cellular, and Molecular Aspects in the Pathophysiology of Rosacea
Martin Steinhoff,Jörg Buddenkotte,Jérôme Aubert,Mathias Sulk,Pawel Novak,Verena D. Schwab,Christian Mess,Ferda Cevikbas,Michel Rivier,Isabelle Carlavan,Sophie Deret,Carine Rosignoli,Dieter Metze,Thomas A. Luger,Johannes Voegel +14 more
TL;DR: A review of recent molecular (gene array) and cellular findings and aims to integrate the different body defense mechanisms into a modern concept of rosacea pathophysiology, suggesting a strong connection between chronic inflammatory processes and skin fibrosis development.
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Neurovascular and neuroimmune aspects in the pathophysiology of rosacea.
Verena D. Schwab,Mathias Sulk,Stephan Seeliger,Pawel Nowak,Jérôme Aubert,Christian Mess,Michel Rivier,Isabelle Carlavan,Patricia Rossio,Dieter Metze,Jörg Buddenkotte,Ferda Cevikbas,Johannes Voegel,Martin Steinhoff,Martin Steinhoff +14 more
TL;DR: Dysregulation of mediators and receptors implicated in neurovascular and neuroimmune communication may be crucial at early stages of rosacea.