Jörg Buddenkotte

TL;DR: The activation of a new subfamily of G protein-coupled receptors, termed proteinase-activated receptors (PARs), necessitates a paradigm shift in thinking about hormone action, to include proteinases as key modulators of biological function.

TL;DR: VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation.

TL;DR: A review of recent molecular (gene array) and cellular findings and aims to integrate the different body defense mechanisms into a modern concept of rosacea pathophysiology, suggesting a strong connection between chronic inflammatory processes and skin fibrosis development.

TL;DR: Dysregulation of mediators and receptors implicated in neurovascular and neuroimmune communication may be crucial at early stages of rosacea.

TL;DR: The pruritus- and TH2-associated novel cytokine IL-31 induces a distinct transcriptional program in sensory neurons, leading to nerve elongation and branching both in vitro and in-vivo, which might help to understand the clinical observation that patients with atopic dermatitis experience increased sensitivity to minimal stimuli inducing sustained itch.