J
Johannes Wichmann
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 3
Citations - 170
Johannes Wichmann is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Acetylation & Histone. The author has an hindex of 1, co-authored 1 publications receiving 98 citations. Previous affiliations of Johannes Wichmann include University of Melbourne.
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Journal ArticleDOI
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
Jonathan B. Baell,Jonathan B. Baell,David J. Leaver,S.J. Hermans,Gemma L. Kelly,Gemma L. Kelly,Margs S. Brennan,Margs S. Brennan,Natalie L. Downer,Nghi H. Nguyen,Johannes Wichmann,Johannes Wichmann,Helen M. McRae,Helen M. McRae,Yuquing Yang,Yuquing Yang,Benjamin Cleary,H. Rachel Lagiakos,Stephen Mieruszynski,Stephen Mieruszynski,Guido Pacini,Hannah K. Vanyai,Hannah K. Vanyai,Maria I. Bergamasco,Maria I. Bergamasco,Rose E. May,Bethany K. Davey,Kimberly J. Morgan,Kimberly J. Morgan,Andrew J. Sealey,Andrew J. Sealey,Beinan Wang,Beinan Wang,Beinan Wang,Natasha Zamudio,Natasha Zamudio,Stephen Wilcox,Stephen Wilcox,Alexandra L. Garnham,Alexandra L. Garnham,Bilal N. Sheikh,Bilal N. Sheikh,Brandon J. Aubrey,Brandon J. Aubrey,Karen Doggett,Karen Doggett,M.C. Chung,Melanie de Silva,John D. Bentley,Pat Pilling,Meghan Hattarki,Olan Dolezal,Matthew L. Dennis,Hendrik Falk,Hendrik Falk,Bin Ren,Susan A. Charman,Karen L. White,Jai Rautela,Jai Rautela,Andrea Newbold,Edwin D. Hawkins,Edwin D. Hawkins,Ricky W. Johnstone,Nicholas D. Huntington,Nicholas D. Huntington,Thomas S. Peat,Joan K. Heath,Joan K. Heath,Andreas Strasser,Andreas Strasser,Michael W. Parker,Michael W. Parker,Gordon K. Smyth,Gordon K. Smyth,Ian P. Street,Ian P. Street,Brendon J. Monahan,Brendon J. Monahan,Anne K. Voss,Anne K. Voss,Tim Thomas,Tim Thomas +82 more
TL;DR: Biochemical and structural studies demonstrate that these compounds are reversible competitors of acetyl coenzyme A and inhibit MYST-catalysed histone acetylation, induce cell cycle exit and cellular senescence without causing DNA damage, and arrest lymphoma progression in mouse models.
Journal ArticleDOI
Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest
Johannes Wichmann,Catherine Pitt,Samantha Eccles,Alexandra L. Garnham,Connie S N Li-Wai-Suen,Rose E. May,Elizabeth Allan,Stephen Wilcox,Marco J Herold,Gordon K. Smyth,Brendon J. Monahan,Tim Thomas,Anne K. Voss +12 more
TL;DR: In this paper , the role of histone lysine acetyltransferase TIP60 (KAT5/HTATIP) was investigated in human cells, mouse cells, and mouse embryos.
Journal ArticleDOI
The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance
Melanie Heinlein,Luke C. Gandolfo,Kelin Zhao,Charis E Teh,Nghi H. Nguyen,Jonathan B. Baell,Yael Goldfarb,Jakub Abramson,Johannes Wichmann,Anne K. Voss,Andreas Strasser,Gordon K. Smyth,Tim Thomas,Daniel H.D. Gray +13 more
TL;DR: It is found that KAT7 is required for optimal expansion of medullary TEC and has a major role in the expression of AIRE-dependent PTGs, associated with enhanced chromatin accessibility at these gene loci in TECs.