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Nicholas D. Huntington
Researcher at Monash University, Clayton campus
Publications - 145
Citations - 11945
Nicholas D. Huntington is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: Immune system & Cellular differentiation. The author has an hindex of 49, co-authored 137 publications receiving 9323 citations. Previous affiliations of Nicholas D. Huntington include Discovery Institute & Bill & Melinda Gates Foundation.
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Journal ArticleDOI
ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim
Hamsa Puthalakath,Lorraine A. O'Reilly,Priscilla Gunn,Lily Lee,P N Kelly,P N Kelly,Nicholas D. Huntington,Peter Hughes,Peter Hughes,Ewa M. Michalak,Jennifer L. McKimm-Breschkin,Noburo Motoyama,Tomomi Gotoh,Shizuo Akira,Philippe Bouillet,Andreas Strasser +15 more
TL;DR: It is found that Bim is essential for ER stress-induced apoptosis in a diverse range of cell types both in culture and within the whole animal.
Journal ArticleDOI
Targeting natural killer cells in cancer immunotherapy
Camille Guillerey,Camille Guillerey,Nicholas D. Huntington,Nicholas D. Huntington,Mark J. Smyth,Mark J. Smyth +5 more
TL;DR: Diverse approaches encompass the development of large-scale NK cell–expansion protocols for adoptive transfer, the establishment of a microenvironment favorable toNK cell activity, the redirection of NK cell activity against tumor cells and the release of inhibitory signals that limit NK cell function.
Journal ArticleDOI
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.
Nicholas D. Huntington,Nicolas Legrand,Nuno L. Alves,Barbara Jaron,Kees Weijer,Ariane Plet,Erwan Corcuff,Erwan Mortier,Yannick Jacques,Hergen Spits,James P. Di Santo +10 more
TL;DR: These data provide the first evidence that IL-15 trans-presentation regulates human NK cell homeostasis, and use of hIL-15 receptor agonists generates a robust humanized immune system model to study human NK cells in vivo.
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Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells
Yulong Gao,Yulong Gao,Fernando Souza-Fonseca-Guimaraes,Fernando Souza-Fonseca-Guimaraes,Fernando Souza-Fonseca-Guimaraes,Tobias Bald,Susanna S. Ng,Susanna S. Ng,Arabella Young,Arabella Young,Shin Foong Ngiow,Jai Rautela,Jasmin Straube,Nic Waddell,Stephen J. Blake,Juming Yan,Juming Yan,Laurent Bartholin,Jason Sang Hun Lee,Eric Vivier,Kazuyoshi Takeda,Meriem Messaoudene,Laurence Zitvogel,Laurence Zitvogel,Michele W.L. Teng,Michele W.L. Teng,Gabrielle T. Belz,Christian R. Engwerda,Nicholas D. Huntington,Kyohei Nakamura,Michael Hölzel,Mark J. Smyth,Mark J. Smyth +32 more
TL;DR: These findings provide new insight into the plasticity of group 1 ILCs in the tumor microenvironment and suggest that the TGF-β-driven conversion of NK cells into ILC1s is a previously unknown mechanism by which tumors escape surveillance by the innate immune system.
Journal ArticleDOI
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
Sébastien Viel,Antoine Marçais,Fernando Souza Fonseca Guimaraes,Fernando Souza Fonseca Guimaraes,Róisín M. Loftus,Jessica Rabilloud,Morgan Grau,Sophie Degouve,Sophia Djebali,Amélien Sanlaville,Emily Charrier,Jacques Bienvenu,Julien C. Marie,Julien C. Marie,Christophe Caux,Jacqueline Marvel,Liam Town,Nicholas D. Huntington,Laurent Bartholin,David K. Finlay,Mark J. Smyth,Mark J. Smyth,Thierry Walzer +22 more
TL;DR: The results suggest that boosting the metabolic activity of antitumor lymphocytes could be an effective strategy to promote immune-mediated tumor suppression and provide genetic, pharmacologic, and biochemical evidence that the kinase mTOR is a crucial signaling integrator of pro- and anti-inflammatory cytokines in NK cells.