M
Margs S. Brennan
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 13
Citations - 1506
Margs S. Brennan is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cancer & Transgene. The author has an hindex of 7, co-authored 10 publications receiving 1123 citations. Previous affiliations of Margs S. Brennan include University of Melbourne.
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Journal ArticleDOI
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
András Kotschy,Szlávik Zoltán,James A. H. Murray,James Edward Paul Davidson,Ana Leticia Maragno,Gaëtane Le Toumelin-Braizat,Maïa Chanrion,Gemma L. Kelly,Gemma L. Kelly,Jia-Nan Gong,Jia-Nan Gong,Donia M Moujalled,Alain Bruno,Csékei Márton,Attila Paczal,Zoltán B. Szabó,Szabolcs Sipos,Gabor Radics,Proszenyák Ágnes,Balázs Bálint,Levente Ondi,Gábor Blasko,Alan P. Robertson,Allan E. Surgenor,Pawel Dokurno,Chen I-Jen,Natalia Matassova,Julia Smith,C. Pedder,Chris Graham,Aurélie Studeny,Gaëlle Lysiak-Auvity,Anne-Marie Girard,Fabienne Gravé,David J. Segal,David J. Segal,Chris D. Riffkin,Chris D. Riffkin,Giovanna Pomilio,Laura C. A. Galbraith,Laura C. A. Galbraith,Brandon J. Aubrey,Brandon J. Aubrey,Brandon J. Aubrey,Margs S. Brennan,Margs S. Brennan,Marco J Herold,Marco J Herold,Catherine Chang,Catherine Chang,Ghislaine Guasconi,Nicolas Cauquil,Fabien Melchiore,Nolwen Guigal-Stephan,Brian Lockhart,Frédéric Colland,John A. Hickman,Andrew W. Roberts,David C.S. Huang,David C.S. Huang,Andrew H. Wei,Andrew H. Wei,Andreas Strasser,Andreas Strasser,Guillaume Lessene,Guillaume Lessene,Olivier Geneste +66 more
TL;DR: It is demonstrated that S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
Journal ArticleDOI
An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo
Brandon J. Aubrey,Gemma L. Kelly,Andrew J. Kueh,Andrew J. Kueh,Margs S. Brennan,Margs S. Brennan,Liam O’Connor,Liam O’Connor,Liz Milla,Liz Milla,Stephen Wilcox,Stephen Wilcox,Lin Tai,Andreas Strasser,Andreas Strasser,Marco J Herold,Marco J Herold +16 more
TL;DR: A drug-inducible small guide RNA (sgRNA) vector system allowing for ubiquitous and efficient gene deletion in murine and human cells mediates the efficient, temporally controlled deletion of MCL-1 in human Burkitt lymphoma cell lines that require this anti-apoptotic BCL-2 protein for sustained survival and growth.
Journal ArticleDOI
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
Jonathan B. Baell,Jonathan B. Baell,David J. Leaver,S.J. Hermans,Gemma L. Kelly,Gemma L. Kelly,Margs S. Brennan,Margs S. Brennan,Natalie L. Downer,Nghi H. Nguyen,Johannes Wichmann,Johannes Wichmann,Helen M. McRae,Helen M. McRae,Yuquing Yang,Yuquing Yang,Benjamin Cleary,H. Rachel Lagiakos,Stephen Mieruszynski,Stephen Mieruszynski,Guido Pacini,Hannah K. Vanyai,Hannah K. Vanyai,Maria I. Bergamasco,Maria I. Bergamasco,Rose E. May,Bethany K. Davey,Kimberly J. Morgan,Kimberly J. Morgan,Andrew J. Sealey,Andrew J. Sealey,Beinan Wang,Beinan Wang,Beinan Wang,Natasha Zamudio,Natasha Zamudio,Stephen Wilcox,Stephen Wilcox,Alexandra L. Garnham,Alexandra L. Garnham,Bilal N. Sheikh,Bilal N. Sheikh,Brandon J. Aubrey,Brandon J. Aubrey,Karen Doggett,Karen Doggett,M.C. Chung,Melanie de Silva,John D. Bentley,Pat Pilling,Meghan Hattarki,Olan Dolezal,Matthew L. Dennis,Hendrik Falk,Hendrik Falk,Bin Ren,Susan A. Charman,Karen L. White,Jai Rautela,Jai Rautela,Andrea Newbold,Edwin D. Hawkins,Edwin D. Hawkins,Ricky W. Johnstone,Nicholas D. Huntington,Nicholas D. Huntington,Thomas S. Peat,Joan K. Heath,Joan K. Heath,Andreas Strasser,Andreas Strasser,Michael W. Parker,Michael W. Parker,Gordon K. Smyth,Gordon K. Smyth,Ian P. Street,Ian P. Street,Brendon J. Monahan,Brendon J. Monahan,Anne K. Voss,Anne K. Voss,Tim Thomas,Tim Thomas +82 more
TL;DR: Biochemical and structural studies demonstrate that these compounds are reversible competitors of acetyl coenzyme A and inhibit MYST-catalysed histone acetylation, induce cell cycle exit and cellular senescence without causing DNA damage, and arrest lymphoma progression in mouse models.
Journal ArticleDOI
DNA repair processes are critical mediators of p53-dependent tumor suppression.
Ana Janic,Ana Janic,Liz J. Valente,Liz J. Valente,Liz J. Valente,Matthew Wakefield,Matthew Wakefield,Leon Di Stefano,Liz Milla,Liz Milla,Stephen Wilcox,Stephen Wilcox,Haoyu Yang,Haoyu Yang,Haoyu Yang,Lin Tai,Cassandra J. Vandenberg,Cassandra J. Vandenberg,Andrew J. Kueh,Andrew J. Kueh,Shinsuke Mizutani,Shinsuke Mizutani,Margs S. Brennan,Margs S. Brennan,Robyn L Schenk,Robyn L Schenk,Lisa M Lindqvist,Lisa M Lindqvist,Anthony T. Papenfuss,Anthony T. Papenfuss,Anthony T. Papenfuss,Liam O’Connor,Liam O’Connor,Andreas Strasser,Andreas Strasser,Marco J Herold,Marco J Herold +36 more
TL;DR: Findings demonstrate that extensive functional overlap of several p53-regulated processes safeguards against cancer and that coordination of DNA repair appears to be an important process by which p53 suppresses tumor development.
Journal ArticleDOI
Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use
Margs S. Brennan,Catherine Chang,Lin Tai,Guillaume Lessene,Guillaume Lessene,Andreas Strasser,Grant Dewson,Gemma L. Kelly,Marco J Herold +8 more
TL;DR: The potential of the huMcl-1 mouse model for testing MCL-1 inhibitors, allowing precise predictions of efficacy and tolerability for clinical translation, is demonstrated.