J
John B. Little
Researcher at Harvard University
Publications - 473
Citations - 24662
John B. Little is an academic researcher from Harvard University. The author has contributed to research in topics: Cell culture & Cell killing. The author has an hindex of 80, co-authored 472 publications receiving 24115 citations. Previous affiliations of John B. Little include Medical Research Council & University of California, Berkeley.
Papers
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Journal ArticleDOI
Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know
David J. Brenner,Richard Doll,Dudley T. Goodhead,Eric J. Hall,Charles E. Land,John B. Little,Jay H. Lubin,Dale L. Preston,R. Julian Preston,Jerome S. Puskin,Elaine Ron,Rainer K. Sachs,Jonathan M. Samet,Richard B. Setlow,Marco Zaider +14 more
TL;DR: The difficulties involved in quantifying the risks of low-dose radiation are reviewed, a linear extrapolation of cancer risks from intermediate to very low doses currently appears to be the most appropriate methodology, and a linearity assumption is not necessarily the most conservative approach.
Journal Article
Induction of sister chromatid exchanges by extremely low doses of alpha-particles.
Hatsumi Nagasawa,John B. Little +1 more
TL;DR: Results indicate that genetic damage may be induced by low doses of alpha-radiation in cell nuclei not actually traversed by an alpha-particle in hamster ovary cells irradiated with plutonium-238 source.
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Significance of the relationship between lung recoil and maximum expiratory flow.
TL;DR: A theoretical relationship between the static recoil of lungs and the maximum rate at which gas can be expelled from them is developed and the configuration of maximum expiratory flow-volume curves are found.
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Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from α-particle irradiated to nonirradiated cells
TL;DR: It is shown that nonirradiated "bystander" cells participate in the overall response of confluent density-inhibited populations of cultured fibroblast and epithelial cells, and direct evidence is presented for the involvement of connexin43-mediated intercellular communication in the transmission of damage signals to nonIRradiated cells.
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Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles.
TL;DR: Studies at the gene expression level indicate that similar signaling pathways are induced in bystander cells that are not traversed by an alpha particle as in traversed cells, and that biological effects in cell populations are not restricted to the response of individual cells to the DNA damage they receive.