J
John Callegari
Publications - 1
Citations - 552
John Callegari is an academic researcher. The author has contributed to research in topics: Haematopoiesis & Genetic enhancement. The author has an hindex of 1, co-authored 1 publications receiving 535 citations.
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Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin
Chad May,Stefano Rivella,John Callegari,Glenn Heller,Karen M. L. Gaensler,Lucio Luzzatto,Michel Sadelain +6 more
TL;DR: It is shown that the use of recombinant lentiviruses enables efficient transfer and faithful integration of the human β-globin gene together with large segments of its locus control region, which should be of therapeutic benefit in patients with severe defects in haemoglobin production.