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Chad May
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 21
Citations - 2593
Chad May is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Genetic enhancement & Globin. The author has an hindex of 13, co-authored 19 publications receiving 2483 citations. Previous affiliations of Chad May include Pfizer & Cornell University.
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Journal ArticleDOI
Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells
Jason M. Butler,Daniel J. Nolan,Eva L. Vertes,Barbara Varnum-Finney,Hideki Kobayashi,Andrea T. Hooper,Marco Seandel,Marco Seandel,Koji Shido,Ian A. White,Mariko Kobayashi,Larry Witte,Chad May,Carrie J. Shawber,Yuki Kimura,Jan Kitajewski,Zev Rosenwaks,Irwin D. Bernstein,Shahin Rafii +18 more
TL;DR: Angiogenic models are developed to demonstrate that EC-derived angiocrine growth factors support in vitro self-renewal and in vivo repopulation of authentic LT-HSCs, and establish an instructive vascular niche for clinical-scale expansion of LT- HSCs and a cellular platform to identify stem cell-active trophogens.
Journal ArticleDOI
Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin
Chad May,Stefano Rivella,John Callegari,Glenn Heller,Karen M. L. Gaensler,Lucio Luzzatto,Michel Sadelain +6 more
TL;DR: It is shown that the use of recombinant lentiviruses enables efficient transfer and faithful integration of the human β-globin gene together with large segments of its locus control region, which should be of therapeutic benefit in patients with severe defects in haemoglobin production.
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Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling
Loic Vincent,Pouneh Kermani,Lauren M. Young,Joseph Cheng,Fan Zhang,Koji Shido,George Lam,Heidi Bompais-Vincent,Zhenping Zhu,Daniel J. Hicklin,Peter Bohlen,David J. Chaplin,Chad May,Shahin Rafii +13 more
TL;DR: Combined treatment with anti-VE-cadherin agents in conjunction with microtubule-disrupting agents provides a novel synergistic strategy to selectively disrupt assembly and induce regression of nascent tumor neovessels, with minimal toxicity and without affecting normal stabilized vasculature.
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A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human β-globin gene transfer
TL;DR: An adult animal model for the most severe of the hemoglobinopathies, Cooley anemia, is established and the remarkable efficacy of lentivirus-mediated globin gene transfer in treating a fulminant blood disorder is demonstrated and strongly support the efficacy of gene therapy in the severe hemoglobinopathy.
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Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes.
Guenther Koehne,Mikhail Doubrovin,Ekaterina Doubrovina,Pat Zanzonico,Humilidad F. Gallardo,Anna Ivanova,Julius Balatoni,Julie Teruya-Feldstein,Glenn Heller,Chad May,Vladimir Ponomarev,Shutian Ruan,Ronald D. Finn,Ronald G. Blasberg,William Bornmann,Isabelle Riviere,Michel Sadelain,Richard J. O'Reilly,Steven M. Larson,Juri Gelovani Tjuvajev +19 more
TL;DR: It is demonstrated that Epstein-Barr virus (EBV)–specific T cells transduced with vectors encoding herpes simplex virus-1 thymidine kinase (HSV-TK) selectively accumulate radiolabeled 2′-fluoro-2′-deoxy-1-β-D-arabinofuranosyl-5-iodouracil (FIAU) in tumors and tissues.