John Crum

TL;DR: It is suggested that the SH3 domain of endophilin participates in both fission and uncoating and that it may be a key component of a molecular switch that couples the fission reaction to un coating.

TL;DR: The presence of omega profiles on the plasma membrane around active zones, in the same locations as coated pits and coated vesicles labeled with an extracellular marker, suggests that local membrane recycling may contribute to the three- to 14-fold greater abundance of vesicle in the cytoplasm near synapses than in nonsynaptic regions.

TL;DR: In this paper, electron tomography of frog saccular hair cells was used to reconstruct presynaptic ultrastructure at synapses specialized for sustained transmitter release, showing that synapse vesicles at inhibited synapses were abundant in the cytoplasm and covered the synaptic body at high density.

TL;DR: Gene replacement has been used to produce mice expressing normal levels of the three neurofilament subunits, but which are deleted in the known phosphorylation sites within either NF-M or within both NF-H, revealing that the tail domain ofNF-M, with seven KSP motifs, is an essential target for the myelination-dependent outside-in signaling cascade that determines axonal caliber and conduction velocity of motor axons.

TL;DR: It is suggested that the incorporation of BST-2 into viral envelopes underlies its broad restrictive activity, whereas its relative exclusion from virions and sites of viral assembly by proteins such as HIV-1 Vpu may provide viral antagonism of restriction.