O
Oleg Shupliakov
Researcher at Karolinska Institutet
Publications - 111
Citations - 9808
Oleg Shupliakov is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Synaptic vesicle & Active zone. The author has an hindex of 45, co-authored 108 publications receiving 8996 citations. Previous affiliations of Oleg Shupliakov include Yale University & Chalmers University of Technology.
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Journal ArticleDOI
A Pericyte Origin of Spinal Cord Scar Tissue
Christian Göritz,David O. Dias,Nikolay Tomilin,Mariano Barbacid,Oleg Shupliakov,Jonas Frisén +5 more
TL;DR: The formation of connective tissue is common to many injuries and pathologies, and here it is shown that a specific pericyte subtype gives rise to scar-forming stromal cells in the injured spinal cord.
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Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
Konstantinos Meletis,Fanie Barnabé-Heider,Marie Carlén,Emma Evergren,Nikolay Tomilin,Oleg Shupliakov,Jonas Frisén +6 more
TL;DR: Using genetic fate mapping, it is shown that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal.
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Evidence for neurogenesis in the adult mammalian substantia nigra
Ming Zhao,Stefan Momma,Kioumars Delfani,Marie Carlén,Robert Cassidy,Clas B. Johansson,Hjalmar Brismar,Oleg Shupliakov,Jonas Frisén,Ann Marie Janson +9 more
TL;DR: Evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain is provided and it is shown that the rate of neurogenesis is increased after a lesion.
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Distinct pools of synaptic vesicles in neurotransmitter release
Vincent A. Pieribone,Oleg Shupliakov,Lennart Brodin,Sabine Hilfiker-Rothenfluh,Andrew J. Czernik,Paul Greengard +5 more
TL;DR: It is shown that clusters of vesicles at synaptic release sites are composed of two pools, a distal pool containing synapsin and a proximal pool devoid of synAPSin and located adjacent to the presynaptic membrane.
Journal ArticleDOI
Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions.
Oleg Shupliakov,Oleg Shupliakov,Peter Löw,Peter Löw,Detlev Grabs,Detlev Grabs,Helge Gad,Helge Gad,Hong Chen,Hong Chen,Carol David,Carol David,Kohji Takei,Kohji Takei,Pietro De Camilli,Pietro De Camilli,Lennart Brodin,Lennart Brodin +17 more
TL;DR: It is demonstrated that SH3-mediated interactions are required for dynamin function and support an essential role of clathrin-mediated endocytosis in synaptic vesicle recycling.