John D. Olson

TL;DR: Seven of 8 delayed traumatic intracerebral hematomas were associated with clotting abnormalities suggesting disseminated intravascular clotting and fibrinolysis (DICF), which suggests an increased risk of bleeding in association with the insertion of ventricular catheters in patients with DICF.

TL;DR: It is defective attachment of exogenous vWF which prevents vWF-mediated agglutination of BSS platelets, rather than defective platelet-to-platelet contact subsequent tovWF-BSS platelet binding.

TL;DR: SDS-slab gel electrophoresis revealed that the prothrombin present in the patient's eluate was cleaved by Echis carinatus venom, suggesting that the coagulopathy of prothrome results from the generation of a dysfunctional thrombin.

TL;DR: The results indicate that (1) the initial binding of human vWF polymers to platelets is a specific interaction which requires the presence of ristocetin; (2) ristOCetin andhuman vWF do not form persistent complexes in solution; and (3) the association of ristsocet in and platelets are of low affinity.

TL;DR: It is concluded that FVIIIvWF-mediated agglutination requires both functional platelet FV IIIvWF binding sites and platelet-platelet cohesion sites, and that platelet surface cohesion sites are altered by AET and PGI2.