J
Junhao Yan
Researcher at Peking University
Publications - 32
Citations - 1340
Junhao Yan is an academic researcher from Peking University. The author has contributed to research in topics: Subarachnoid hemorrhage & Perforation (oil well). The author has an hindex of 16, co-authored 27 publications receiving 1112 citations. Previous affiliations of Junhao Yan include Loma Linda University Medical Center & Loma Linda University.
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Journal ArticleDOI
Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research
Mutsumi Fujii,Junhao Yan,William B. Rolland,Yoshiteru Soejima,Basak Caner,John H. Zhang,John H. Zhang +6 more
TL;DR: It could be argued that the treatment of EBI may successfully attenuate some of the devastating secondary injuries and improve the outcome of patients with SAH and the reversal of vasospasm does not appear to improve patient outcome.
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Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats
Chunhua Chen,Qin Hu,Junhao Yan,Xiaomei Yang,Xianzhong Shi,Jiliang Lei,Lin Chen,Hongyun Huang,Jing-Yan Han,John H. Zhang,Changman Zhou +10 more
TL;DR: HIF-1alpha siRNA may protect the ischemic-reperfused neurons in vivo via inhibition of HIF- 1alpha, its downstream VEGF and other apoptotic-related proteins such as p53 and Caspase-3 and may have potentials for the early treatment of isChemic cerebral stroke.
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Multiple effects of 2ME2 and D609 on the cortical expression of HIF‐1α and apoptotic genes in a middle cerebral artery occlusion‐induced focal ischemia rat model
Chunhua Chen,Qin Hu,Junhao Yan,Jiliang Lei,Lihua Qin,Xianzhong Shi,Liju Luan,Lei Yang,Ke Wang,Jing-Yan Han,Anil Nanda,Changman Zhou +11 more
TL;DR: 2ME2 and D609 are powerful agents to protect brain from cerebral ischemic injury by inhibiting HIF‐1α expression, attenuating the superfluous expression of VEGF to avoid blood–brain barrier disruption and suppressing neuronal apoptosis via BNIP3 pathway.
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Nasal Administration of Recombinant Osteopontin Attenuates Early Brain Injury After Subarachnoid Hemorrhage
TL;DR: Nasal administration of rOPN decreased neuronal cell death and brain edema and improved the neurological status in SAH rats, possibly through FAK–phosphatidylinositol 3-kinase–Akt–induced inhibition of capase-3 cleavage.
Journal ArticleDOI
Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model
Qin Hu,Chunhua Chen,Chunhua Chen,Junhao Yan,Xiaomei Yang,Xianzhong Shi,Jing Zhao,Jiliang Lei,Lei Yang,Ke Wang,Lin Chen,Hongyun Huang,Jing-Yan Han,John H. Zhang,Changman Zhou +14 more
TL;DR: Evidence is provided that a liposomal formulation of siRNA might be used in vivo to silence the MMP-9 gene and could potentially serve as an important therapeutic alternative in patients with cerebral ischemia.