John McCafferty

TL;DR: It is shown explicitly that G-quadruplex formation in DNA is modulated during cell-cycle progression and that endogenous G- quadruplex DNA structures can be stabilized by a small-molecule ligand and corroborate the application of stabilizing ligands in a cellular context to target G- Quadruplexes and intervene with their function.

TL;DR: This work shows that conventional hybridoma technology may be superseded by large phage libraries that are proving to be a stable and reliable source of specific, high affinity human monoclonal antibodies.

TL;DR: The filamentous bacteriophage is a cDNA cloning system based on filamentous phage - selection and enrichment of functional gene products by protein/ligand interactions made possible by linkage of recognition and replication functions.

TL;DR: The amenability of in vitro display to high-throughput applications broadens the prospects for their wider use in basic and applied research.

TL;DR: The potential of and the issues associated with genome-wide monoclonal antibody generation are demonstrated and illuminated by a high quality phage display library containing over 1010 human antibodies.