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Stefan Dübel
Researcher at Braunschweig University of Technology
Publications - 253
Citations - 10717
Stefan Dübel is an academic researcher from Braunschweig University of Technology. The author has contributed to research in topics: Phage display & Antibody. The author has an hindex of 58, co-authored 246 publications receiving 9507 citations. Previous affiliations of Stefan Dübel include University of Regensburg & Siemens.
Papers
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Journal ArticleDOI
Beyond natural antibodies: the power of in vitro display technologies
TL;DR: The amenability of in vitro display to high-throughput applications broadens the prospects for their wider use in basic and applied research.
Patent
Phagemide for screening antibodies
TL;DR: In this article, a phagemide has been constructed that expresses an antibody merged to coliphage pIII protein, which is suitable for selecting specific antibodies from large gene banks with small quantities of antigen.
Journal ArticleDOI
Designing Human Antibodies by Phage Display
André Frenzel,Jonas Kügler,Saskia Helmsing,Doris Meier,Thomas Schirrmann,Michael Hust,Stefan Dübel +6 more
TL;DR: Some opportunities and achievements are summarized, e.g., the generation of antibodies which could not be generated otherwise, and the design of antibody properties by different panning strategies, including the adjustment of kinetic parameters.
Journal ArticleDOI
A surface expression vector for antibody screening.
TL;DR: A phagemid that expresses a single-chain Ab fused to pIII, a coliphage protein product of gene III that initiates infection by binding to F pili is constructed, which can be tightly repressed so that Ab libraries can be amplified without risk of being dominated by deletion mutants.
Journal ArticleDOI
A helper phage to improve single-chain antibody presentation in phage display
TL;DR: It is shown that the number of single-chain antibody fragments presented on filamentous phage particles generated with antibody display phagemids can be increased by more than two orders of magnitude by using a newly developed helper phage (hyperphage).