J
John N. Waitumbi
Researcher at Kenya Medical Research Institute
Publications - 81
Citations - 3208
John N. Waitumbi is an academic researcher from Kenya Medical Research Institute. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 31, co-authored 72 publications receiving 2887 citations. Previous affiliations of John N. Waitumbi include United States Army Medical Research Unit-Kenya & Hebrew University of Jerusalem.
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Journal ArticleDOI
Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya.
Bernhards Ogutu,Odika J. Apollo,Denise McKinney,Willis Okoth,Joram Siangla,Filip Dubovsky,Kathryn Tucker,John N. Waitumbi,Carter L. Diggs,Janet Wittes,Elissa Malkin,Amanda J. Leach,Lorraine Soisson,Jessica Milman,Lucas Otieno,Carolyn A. Holland,Mark E. Polhemus,Shon Remich,Christian F. Ockenhouse,Joe Cohen,W. Ripley Ballou,Samuel K. Martin,Evelina Angov,V. Ann Stewart,Jeffrey A. Lyon,D. Gray Heppner,Mark R. Withers +26 more
TL;DR: FMP1/AS02 had a good safety profile and was well-tolerated but more reactogenic than the comparator, and is not a promising candidate for further development as a monovalent malaria vaccine.
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Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya
Robert N Maina,Douglas S. Walsh,Douglas S. Walsh,Charla E. Gaddy,Charla E. Gaddy,Gordon Hongo,Gordon Hongo,John N. Waitumbi,John N. Waitumbi,Lucas Otieno,Lucas Otieno,David Jones,David Jones,Bernhards Ogutu,Bernhards Ogutu +14 more
TL;DR: Children infected with Plasmodium falciparum malaria exhibited important changes in some haematological parameters with low platelet count and haemoglobin concentration being the two most important predictors of malaria infection in children in the study area.
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Red cell surface changes and erythrophagocytosis in children with severe plasmodium falciparum anemia.
TL;DR: The surface of red cells of children with severe P falciparum anemia is modified by the deposition of IgG and alterations in the levels of complement regulatory proteins, which could contribute to the accelerated destruction ofred cells in these patients by mechanisms such as phagocytosis or complement-mediated lysis.
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Development of a Highly Sensitive Genus-Specific Quantitative Reverse Transcriptase Real-Time PCR Assay for Detection and Quantitation of Plasmodium by Amplifying RNA and DNA of the 18S rRNA Genes
Edwin Kamau,LaDonna S. Tolbert,Luke Kortepeter,Michael Pratt,Nancy Nyakoe,Linda Muringo,Bernard Ogutu,John N. Waitumbi,Christian F. Ockenhouse +8 more
TL;DR: Analysis of total nucleic acids by qRT-PCR is a suitable assay for detection of low parasite levels in patients with early-stage malaria and/or submicroscopic infections and could greatly benefit malaria diagnosis, intervention trials, and malaria control and elimination efforts.
Journal ArticleDOI
Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.
Mark E. Polhemus,Shon Remich,Bernhards Ogutu,John N. Waitumbi,Lucas Otieno,Stella Apollo,James F. Cummings,Kent E. Kester,Christian F. Ockenhouse,Stewart V Ann,Opokua Ofori-Anyinam,Isabelle Ramboer,Conor P. Cahill,Marc Lievens,Marie-Claude Dubois,Marie-Ange Demoitié,Amanda J. Leach,Joe Cohen,W. Ripley Ballou,D. Gray Heppner +19 more
TL;DR: Both candidate malaria vaccines had a good safety profile and were well tolerated over a 12 month surveillance period and both produced strong anti-HBs responses.