J
John O. Trent
Researcher at University of Louisville
Publications - 172
Citations - 10197
John O. Trent is an academic researcher from University of Louisville. The author has contributed to research in topics: G-quadruplex & Cancer. The author has an hindex of 51, co-authored 166 publications receiving 9042 citations. Previous affiliations of John O. Trent include University of Naples Federico II & University of Alabama at Birmingham.
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Discovery and Development of the G-rich Oligonucleotide AS1411 as a Novel Treatment for Cancer
TL;DR: The serendipitous discovery of the G-rich oligonucleotides led to the identification of nucleolin as a new molecular target for cancer therapy, and this molecule functions as an aptamer to nucleolin, a multifunctional protein that is highly expressed by cancer cells, both intracellularly and on the cell surface.
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Stability and kinetics of G-quadruplex structures
TL;DR: An overview of recent literature on the structure and stability of unimolecular G-rich quadruplex structures that are relevant to drug design and for in vivo function and the unifying theme in this review is energetics.
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Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding *
TL;DR: A series of guanosine-rich phosphodiester oligodeoxynucleotides that strongly inhibit proliferation in a number of human tumor cell lines are described and represent a new class of potentially therapeutic agents with a novel mechanism of action.
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Biophysical and biological properties of quadruplex oligodeoxyribonucleotides.
Virna Đapić,Vedra Abdomerović,Rachel Marrington,Jemma C. Peberdy,Alison Rodger,John O. Trent,Paula J. Bates +6 more
TL;DR: It is confirmed that G-quartet formation is essential for biological activity of GROs and show that, in some cases, quadruplex structures formed in the presence of potassium ions are significantly more active than those formed inThe presence of sodium ions.
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Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
Brian F. Clem,Sucheta Telang,Amy L. Clem,Abdullah Yalcin,Jason B. Meier,Alan Simmons,Mary Ann Rasku,Sengodagounder Arumugam,William L. Dean,John W. Eaton,Andrew N. Lane,John O. Trent,Jason Chesney +12 more
TL;DR: 3PO markedly attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines and is selectively cytostatic to ras-transformed human bronchial epithelial cells relative to normal human bronachial epithel cells.