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Alan Simmons
Researcher at University of Kentucky
Publications - 17
Citations - 692
Alan Simmons is an academic researcher from University of Kentucky. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 5, co-authored 7 publications receiving 598 citations. Previous affiliations of Alan Simmons include University of Louisville.
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Journal ArticleDOI
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
Brian F. Clem,Sucheta Telang,Amy L. Clem,Abdullah Yalcin,Jason B. Meier,Alan Simmons,Mary Ann Rasku,Sengodagounder Arumugam,William L. Dean,John W. Eaton,Andrew N. Lane,John O. Trent,Jason Chesney +12 more
TL;DR: 3PO markedly attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines and is selectively cytostatic to ras-transformed human bronchial epithelial cells relative to normal human bronachial epithel cells.
Journal ArticleDOI
Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.
Abdullah Yalcin,Abdullah Yalcin,Brian F. Clem,Alan Simmons,Andrew N. Lane,Kristin K. Nelson,Amy L. Clem,Erin Brock,Deanna Siow,Binks W. Wattenberg,Sucheta Telang,Jason Chesney +11 more
TL;DR: An unexpected role for PFKFB3 in nuclear signaling is demonstrated and it is indicated that Fru-2,6-BP may couple the activation of glucose metabolism with cell proliferation.
Journal ArticleDOI
Early Growth Response Genes Regulate B Cell Development, Proliferation, and Immune Response
Murali Gururajan,Alan Simmons,Trivikram Dasu,Brett T. Spear,Brett T. Spear,Christopher Calulot,Darrell A. Robertson,David L. Wiest,John G. Monroe,Subbarao Bondada +9 more
TL;DR: There was a decrease in B lymphopoiesis in the bone marrow accompanied by a reduction in splenic immature and mature B cells as well as marginal zone B cells in the transgenic mice, which respond poorly to BCR cross-linking in vitro and T-independent and T -dependent Ags in vivo.
Journal ArticleDOI
The Role of MAPKs in B Cell Receptor-induced Down-regulation of Egr-1 in Immature B Lymphoma Cells
Jiyuan Ke,Murali Gururajan,Anupam Kumar,Alan Simmons,Lilia Turcios,Ralph L. Chelvarajan,David M. Cohen,David L. Wiest,John G. Monroe,Subbarao Bondada +9 more
TL;DR: This study suggests that BCR signals reduce egr-1 expression by inhibiting activation of ERK and JNK, unlike the immature B lymphoma cells, which did not exhibit constitutive MAPK activation.
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Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer.
Sarah M. Groves,Geena V. Ildefonso,Caitlin O. McAtee,Patricia Midori Murobushi Ozawa,Abbie S. Ireland,Philip E. Stauffer,Perry T. Wasdin,Xiaomeng Huang,Yi Qiao,Jing Shan Lim,Jackie E. Bader,Qi Liu,Alan Simmons,Ken S. Lau,Wade T. Iams,Douglas P. Hardin,Edward B. Saff,William R. Holmes,Darren R. Tyson,Christine M. Lovly,Jeffrey C. Rathmell,Gabor T. Marth,Julien Sage,Trudy G. Oliver,Alissa M. Weaver,Vito Quaranta +25 more
TL;DR: In this paper , the authors apply an archetypal analysis to model plasticity by recasting SCLC phenotypic heterogeneity through multi-task evolutionary theory, and find that task trade-offs, in response to microenvironmental perturbations or treatment, may drive cell plasticity.