J
John P. Thyfault
Researcher at University of Kansas
Publications - 227
Citations - 9407
John P. Thyfault is an academic researcher from University of Kansas. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 50, co-authored 196 publications receiving 8010 citations. Previous affiliations of John P. Thyfault include Memorial Medical Center & United States Department of Veterans Affairs.
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Journal ArticleDOI
Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms
Frank W. Booth,Christian K. Roberts,John P. Thyfault,Gregory N. Ruegsegger,Ryan G. Toedebusch +4 more
TL;DR: It is proposed that physical inactivity could be considered a behavior selected by evolution for resting, and also selected to be reinforcing in life-threatening situations in which exercise would be dangerous.
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Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
R. Scott Rector,John P. Thyfault,Grace M. Uptergrove,E. Matthew Morris,Scott P. Naples,Sarah J. Borengasser,Catherine R. Mikus,Matthew J. Laye,M. Harold Laughlin,Frank W. Booth,Jamal A. Ibdah +10 more
TL;DR: It is shown that hepatic mitochondrial dysfunction precedes the development of NAFLD and insulin resistance in the OLETF rats, and evidence suggests that progressive mitochondrial dysfunction contributes to the natural history of obesity-associated NA FLD.
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Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans.
Matthew W. Hulver,Jason R. Berggren,Michael J. Carper,Makoto Miyazaki,James M. Ntambi,Eric P. Hoffman,John P. Thyfault,Robert Stevens,G. Lynis Dohm,Joseph A. Houmard,Deborah M. Muoio +10 more
TL;DR: It is shown that the lipogenic gene, stearoyl-CoA desaturase 1 (SCD1), is robustly up-regulated in skeletal muscle from extremely obese humans, and elevated expression of SCD1 in skeletal Muscle contributes to abnormal lipid metabolism and progression of obesity.
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Non-alcoholic fatty liver disease and the metabolic syndrome: An update
TL;DR: Recent findings linking the components of the metabolic syndrome with NAFLD and the progression to nonalcoholic steatohepatitis (NASH) will be reviewed; in particular, the role of visceral adipose tissue, insulin resistance, and adipocytokines in the exacerbation of these conditions are reviewed.
Journal ArticleDOI
Nonalcoholic fatty liver disease and mitochondrial dysfunction.
TL;DR: Accumulating evidence indicate that hepatic mitochondrial dysfunction is crucial to the pathogenesis of NAFLD, and this review is focused on the significant role of mitochondria in the development ofNAFLD.