Ryan G. Toedebusch

TL;DR: It is proposed that physical inactivity could be considered a behavior selected by evolution for resting, and also selected to be reinforcing in life-threatening situations in which exercise would be dangerous.

TL;DR: Recent evidence suggests that the energetic demands of muscle contraction are by themselves stronger controllers of body weight and glucose control than is muscle mitochondrial content.

TL;DR: Interestingly, HVRs presented less Oprd1 mRNA, which ties in to potential differences in dopaminergic signaling between lines, which provides further evidence as to how exercise may be mechanistically regulated.

TL;DR: Neuron maturation in the nucleus accumbens is related to low running voluntary behaviour in the model; this allows researchers to understand the potential neural mechanisms that underlie the motivations for low physical activity behaviour.

TL;DR: This review focuses on the emerging cellular and molecular markers that define sex differences in diabetic cardiomyopathy based on the recent clinical and pre-clinical evidence, and discusses miR-208a, MED13, and AT2R, which may provide new therapeutic targets with hopes to develop novel treatment paradigms to treat diabetic carduomyopathy uniquely between men and women.