John Potokar

TL;DR: Reports of withdrawal symptoms in a retrospective chart review of 352 patients treated in an outpatient clinic with the nonselective serotonin reuptake inhibitor clomipramine or with one of the selective SSRIs, fluoxetine, fluvoxamine, paroxettine, or sertraline suggest a role has been suggested for serotonin in coordinating sensory and autonomic function with motor activity.

TL;DR: Panic disorder is associated with reduced 5-HT(1A) receptor availability, which is also known to have a key role in depression.

TL;DR: Jitteriness/anxiety syndrome remains poorly characterised and clinicians' perception of this syndrome influences prescribing and it is cited to support postulated mechanisms of drug action, but systematised evaluation of side-effects at earlier time points in antidepressant trials to further elucidate this clinically important syndrome.

TL;DR: In this paper, a multisite prospective cohort study was conducted of adults aged 18 years and over referred to liaison psychiatry services following self-harm and evaluated the performance of risk scales (Manchester Self-Harm Rule, ReACT Self Harm Rule, SAD PERSONS scale, Modified SAD Persons scale, Barratt Impulsiveness Scale, etc.).

TL;DR: The use of immune-activated groups at high risk of depression have been used and found novel strategies for the future development of antidepressants including inhibition of indoleamine 2,3-dioxygenase, moderating the cytokines which activate it, or addressing other targets in the kynurenine pathway.