J
John R Glover
Researcher at Howard Hughes Medical Institute
Publications - 6
Citations - 3379
John R Glover is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: AAA proteins & Fungal prion. The author has an hindex of 6, co-authored 6 publications receiving 3233 citations.
Papers
More filters
Journal ArticleDOI
Hsp104, Hsp70, and Hsp40: A Novel Chaperone System that Rescues Previously Aggregated Proteins
John R Glover,Susan Lindquist +1 more
TL;DR: It is concluded that Hsp104 has a protein remodeling activity that acts on trapped, aggregated proteins and requires specific interactions with conventional chaperones to promote refolding of the intermediates it produces.
Journal ArticleDOI
HSP100/Clp proteins: a common mechanism explains diverse functions
TL;DR: The HSP100/Clp proteins are a newly discovered family with a great diversity of functions, such as increased tolerance to high temperatures, promotion of proteolysis of specific cellular substrates and regulation of transcription.
Journal ArticleDOI
Support for the prion hypothesis for inheritance of a phenotypic trait in yeast.
TL;DR: A cytoplasmically inherited genetic element in yeast, [PSI+], was confirmed to be a prionlike aggregate of the cellular protein Sup35 by differential centrifugation analysis and microscopic localization of a Sup35—green fluorescent protein fusion.
Journal ArticleDOI
Self-Seeded Fibers Formed by Sup35, the Protein Determinant of [PSI+], a Heritable Prion-like Factor of S. cerevisiae
TL;DR: It is reported that purified Sup35 and subdomains that induce [PSI+] elements in vivo form highly ordered fibers in vitro, which support a "protein-only" seeded polymerization model for the inheritance of [ PSI+].
Journal ArticleDOI
Defining a Pathway of Communication from the C-Terminal Peptide Binding Domain to the N-Terminal ATPase Domain in a AAA Protein
Anil G. Cashikar,Eric C. Schirmer,Douglas A. Hattendorf,John R Glover,Melarkode S Ramakrishnan,Danielle M. Ware,Susan Lindquist +6 more
TL;DR: This work reports that when one AAA protein, Hsp104, engages polypeptide at the C-terminal peptide-binding region, the ATPase cycle of the C/terminal nucleotide-binding domain (NBD2) drives a conformational change in the middle region, demonstrating the crucial role this region plays in transducing signals from one end of the molecule to the other.