J
John Roote
Researcher at University of Cambridge
Publications - 40
Citations - 4077
John Roote is an academic researcher from University of Cambridge. The author has contributed to research in topics: Drosophila melanogaster & Gene. The author has an hindex of 26, co-authored 40 publications receiving 3841 citations.
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Journal ArticleDOI
Gene disruptions using P transposable elements: an integral component of the Drosophila genome project
TL;DR: Insertions from the collection now lie within or near most Drosophila genes, greatly reducing the time required to identify new mutations and analyze gene functions.
Journal ArticleDOI
The DrosDel Collection: A Set of P-Element Insertions for Generating Custom Chromosomal Aberrations in Drosophila melanogaster
Edward Ryder,Fiona M. Blows,Michael Ashburner,Rosa Bautista-Llacer,Darin Coulson,Jenny Drummond,Jane Webster,David Gubb,Nicola Gunton,Glynnis Johnson,Cahir J. O'Kane,David Huen,Punita Sharma,Zoltan Asztalos,Heiko Baisch,Janet Schulze,Maria Kube,Kathrin Kittlaus,Gunter Reuter,Péter Maróy,János Szidonya,Åsa Rasmuson-Lestander,Karin M. Ekström,Barry J. Dickson,Christoph Hugentobler,Hugo Stocker,Ernst Hafen,Jean Antoine Lepesant,Gert O. Pflugfelder,Martin Heisenberg,Bernard M. Mechler,Florenci Serras,Montserrat Corominas,Stephan Schneuwly,Thomas Preat,John Roote,Steven Russell +36 more
TL;DR: A collection of P-element insertions that have considerable utility for generating custom chromosomal aberrations in Drosophila melanogaster are described and their end points mapped, with base-pair resolution, to the genome sequence.
Journal ArticleDOI
The ribosomal protein genes and Minute loci of Drosophila melanogaster
Steven J Marygold,John Roote,Gunter Reuter,Andrew Lambertsson,Michael Ashburner,Gillian Millburn,Paul M. Harrison,Zhan Yu,Naoya Kenmochi,Thomas C. Kaufman,Sally J. Leevers,Kevin R. Cook +11 more
TL;DR: This work answers a longstanding question about the molecular nature of Minute loci and suggests that Minute phenotypes arise from suboptimal protein synthesis resulting from reduced levels of cytoribosomes.
Journal ArticleDOI
A rapidly evolving MYB-related protein causes species isolation in Drosophila
TL;DR: The cloning of the first, to the authors' knowledge, Drosophila melanogaster gene involved in hybrid incompatibilities, Hybrid male rescue (Hmr) is reported, finding that Hmr encodes a protein with homology to a family of MYB-related DNA-binding transcriptional regulators.
Journal ArticleDOI
The balance between isoforms of the Prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs
David Gubb,Clare Green,David Huen,Darin Coulson,Glynnis Johnson,David Tree,Simon Collier,John Roote +7 more
TL;DR: The phenotypes of pk mutants, and transgenic flies in which the different isoforms are overexpressed show that the balance between Pk and Sple is critical for the specification of planar polarity, and suggest a tessellation model inwhich the alignment of wing hairs is dependent on cell shape and need not reflect fine-grained positional information.