C
Cahir J. O'Kane
Researcher at University of Cambridge
Publications - 101
Citations - 16453
Cahir J. O'Kane is an academic researcher from University of Cambridge. The author has contributed to research in topics: Autophagy & Gene. The author has an hindex of 50, co-authored 99 publications receiving 15391 citations. Previous affiliations of Cahir J. O'Kane include Université libre de Bruxelles & University of Basel.
Papers
More filters
Journal ArticleDOI
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Brinda Ravikumar,Coralie Vacher,Zdenek Berger,Janet E. Davies,Shouqing Luo,Lourdes Garcia Oroz,Francesco Scaravilli,Douglas F. Easton,Rainer Duden,Cahir J. O'Kane,David C. Rubinsztein +10 more
TL;DR: This work shows that mammalian target of rapamycin (mTOR) is sequestered in polyglutamine aggregates in cell models, transgenic mice and human brains, and provides proof-of-principle for the potential of inducing autophagy to treat Huntington disease.
Journal ArticleDOI
Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects
TL;DR: To further the study of synaptic function in a genetically tractable organism and to generate a tool to disable neuronal communication for behavioural studies, a gene encoding tetanus toxin light chain is expressed in Drosophila.
Journal ArticleDOI
Detection in situ of genomic regulatory elements in Drosophila.
TL;DR: The P-lacZ fusion gene is an efficient tool for the recovery of elements that may regulate gene expression in Drosophila and for the generation of a wide variety of cell-type-specific markers.
Journal ArticleDOI
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams,Sovan Sarkar,Paul Cuddon,Evangelia K. Ttofi,Shinji Saiki,Farah H. Siddiqi,Luca Jahreiss,Angeleen Fleming,Dean Pask,Paul Goldsmith,Cahir J. O'Kane,R.A. Floto,David C. Rubinsztein +12 more
TL;DR: A cyclical mTOR-independent pathway regulating autophagy is revealed, in which cAMP regulates IP3 levels, influencing calpain activity, which completes the cycle by cleaving and activating G(s)alpha, which regulates cAMP levels.
Journal ArticleDOI
Lysosomal positioning coordinates cellular nutrient responses
Viktor I. Korolchuk,Shinji Saiki,Maike Lichtenberg,Farah H. Siddiqi,Esteban A. Roberts,Sara Imarisio,Luca Jahreiss,Sovan Sarkar,Marie Futter,Fiona M. Menzies,Cahir J. O'Kane,Vojo Deretic,David C. Rubinsztein +12 more
TL;DR: It is reported that lysosomal positioning coordinates anabolic and catabolic responses with changes in nutrient availability by orchestrating early plasma-membrane signalling events, mTORC1 signalling and autophagy.