G
Gunter Reuter
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 77
Citations - 11906
Gunter Reuter is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Heterochromatin & Position effect. The author has an hindex of 46, co-authored 77 publications receiving 11160 citations. Previous affiliations of Gunter Reuter include Saint Louis University & University of Geneva.
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A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
Gunnar Schotta,Monika Lachner,Kavitha Sarma,Anja Ebert,Roopsha Sengupta,Gunter Reuter,Danny Reinberg,Thomas Jenuwein +7 more
TL;DR: Together, the data indicate a function for H4-K20 trimethylation in gene silencing and further suggest H3-K9 and H4,K20 trimmedethylation as important components of a repressive pathway that can index pericentric heterochromatin.
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Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.
Gunnar Schotta,Anja Ebert,Veiko Krauss,Andreas Fischer,Jan Hoffmann,Stephen Rea,Thomas Jenuwein,Rainer Dorn,Gunter Reuter +8 more
TL;DR: A central role for the SU(VAR)3–9 HMTase in heterochromatin‐induced gene silencing in Drosophila is indicated and the human SUV39H1 gene is able to partially rescue Su(var)3-9 silencing defects.
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The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes.
TL;DR: The homology of Su(var)3‐9 to both negative (Polycomb and Enhancer of zeste) and positive (trithorax) regulators of the Antennapedia and Bithsorax complexes also suggests similarities in the molecular processes connected with stable transmission of a determined state and the clonal propagation of heterochromatinization.
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Functional mammalian homologues of the Drosophila PEV‐modifier Su(var)3‐9 encode centromere‐associated proteins which complex with the heterochromatin component M31
Louise Aagaard,Götz Laible,Philipp Selenko,Manfred Schmid,Rainer Dorn,Gunnar Schotta,Steffi Kuhfittig,Andrea Wolf,Angelika Lebersorger,Prim B. Singh,Gunter Reuter,Thomas Jenuwein +11 more
TL;DR: Immodetection of endogenous Suv39h1/SUV39H1 proteins in a variety of mammalian cell lines reveals enriched distribution at heterochromatic foci during interphase and centromere‐specific localization during metaphase, and indicates the existence of a mammalian SU(VAR) complex.
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Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila
Sarah C. R. Elgin,Gunter Reuter +1 more
TL;DR: Position-effect variegation (PEV) results when a gene normally in euchromatin is juxtaposed with heterochromatin by rearrangement or transposition, and causes transcriptional silencing in a stochastic pattern.