J
John Rose
Researcher at University of Birmingham
Publications - 327
Citations - 9819
John Rose is an academic researcher from University of Birmingham. The author has contributed to research in topics: Intellectual disability & Mental health. The author has an hindex of 50, co-authored 305 publications receiving 9105 citations. Previous affiliations of John Rose include Veterans Health Administration & University of Pittsburgh.
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Journal ArticleDOI
Parenting stress in mothers of children with an intellectual disability: the effects of parental cognitions in relation to child characteristics and family support
R. Hassall,John Rose,J. McDonald +2 more
TL;DR: The results indicated that most of the variance in parenting stress was explained by parental locus of control, parenting satisfaction and child behaviour difficulties, and these results have implications for clinical interventions for promoting parents' coping strategies in managing children with ID and behavioural difficulties.
Journal ArticleDOI
Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution
TL;DR: A comparison of the structures and sequences of these polymerases identifies structural elements that may be responsible for discriminating between ribon nucleotide and deoxyribonucleotide substrates, and RNA and DNA templates.
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The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold.
Zhi-Jie Liu,Yuh-Ju Sun,John Rose,Yong-Je Chung,Chwan-Deng Hsiao,Wen-Rui Chang,Ingrid Kuo,John Perozich,Ronald Lindahl,John Hempel,Bi-Cheng Wang +10 more
TL;DR: Sequence comparisons of the class 3 ALDH with other ALDHs indicate a similar polypeptide fold, novel NAD-binding mode and catalytic site for this family, and a mechanism for enzymatic specificity and activity is postulated.
Journal ArticleDOI
The 2.0 Å structure of human ferrochelatase, the terminal enzyme of heme biosynthesis
TL;DR: The positioning of highly conserved residues in the active site in conjunction with previous biochemical studies support a catalytic model that may have significance in explaining the enzymatic defects that lead to the human inherited disease erythropoietic protoporphyria.
Journal ArticleDOI
Multiple Sclerosis and Related Disorders
Jamie McDonald,Jennifer Graves,Amy Waldman,Timothy Lotze,Teri Schreiner,Anita Belman,Benjamin Greenberg,Bianca Weinstock-Guttman,Gregory Aaen,Jan Mendelt Tillema,Janace Hart,Sabeen Lulu,Jayne Ness,Yolanda Harris,Jennifer Rubin,Meghan Candee,Lauren B. Krupp,Mark Gorman,Leslie Benson,Moses Rodriguez,Tanuja Chitnis,Lisa F. Barcellos,Barbara A. Laraia,John Rose,Shelly Roalstad,Timothy Simmons,T.P Charles,Emmanuelle Waubant +27 more
TL;DR: It is concluded that peripheral blood lymphocyte count is not associated with clinical disease activity reflected by relapses or EDSS progression in fingolimod treated patients, and analysis of specific immune cell subsets as CD4+ lymphocytes is more important to make reliable conclusions regard effectiveness and treatment response.