J
John S. Allen
Researcher at Washington University in St. Louis
Publications - 54
Citations - 3680
John S. Allen is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Molecular imaging & Fumagillin. The author has an hindex of 23, co-authored 54 publications receiving 3511 citations. Previous affiliations of John S. Allen include King's College & University of Washington.
Papers
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Journal ArticleDOI
Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With αvβ3-Integrin–Targeted Nanoparticles
Patrick M. Winter,Anne M. Morawski,Shelton D. Caruthers,Ralph W. Fuhrhop,Huiying Zhang,Todd A. Williams,John S. Allen,Elizabeth K. Lacy,J. David Robertson,Gregory M. Lanza,Samuel A. Wickline +10 more
TL;DR: This molecular imaging approach might provide a method for defining the burden and evolution of atherosclerosis in susceptible individuals as well as responsiveness of individual patients to antiatherosclerotic therapies.
Journal ArticleDOI
Novel MRI Contrast Agent for Molecular Imaging of Fibrin Implications for Detecting Vulnerable Plaques
Sebastian Flacke,Stefan Fischer,Michael J. Scott,Ralph Fuhrhop,John S. Allen,Mark McLean,Patrick M. Winter,Gregorio A. Sicard,Patrick J. Gaffney,Samuel A. Wickline,Gregory M. Lanza +10 more
TL;DR: Fibrin clots targeted in vitro with paramagnetic nanoparticles presented a highly detectable, homogeneous T1-weighted contrast enhancement that improved with increasing gadolinium level, suggesting that molecular imaging of fibrin-targeted param magnetic nanoparticles can provide sensitive detection and localization offibrin.
Journal ArticleDOI
Endothelial ανβ3 Integrin-Targeted Fumagillin Nanoparticles Inhibit Angiogenesis in Atherosclerosis
Patrick M. Winter,Anne M. Neubauer,Shelton D. Caruthers,Thomas D. Harris,J. David Robertson,Todd A. Williams,Anne H. Schmieder,Grace Hu,John S. Allen,Elizabeth K. Lacy,Huiying Zhang,Samuel A. Wickline,Gregory M. Lanza +12 more
TL;DR: The potential of combined molecular imaging and drug delivery with targeted nanoparticles to noninvasively define atherosclerotic burden, to deliver effective targeted drug at a fraction of previous levels, and to quantify local response to treatment is illustrated.
Journal Article
Molecular Imaging of Angiogenesis in Nascent Vx-2 Rabbit Tumors Using a Novel ανβ3-targeted Nanoparticle and 1.5 Tesla Magnetic Resonance Imaging
Patrick M. Winter,Shelton D. Caruthers,Andrea Kassner,Thomas D. Harris,Lori Chinen,John S. Allen,Elizabeth K. Lacy,Huiying Zhang,J. David Robertson,Samuel A. Wickline,Gregory M. Lanza +10 more
TL;DR: The first in vivo use of a magnetic resonance (MR) molecular imaging nanoparticle to sensitively detect and spatially characterize neovascularity induced by implantation of the rabbit Vx-2 tumor using a common clinical field strength is reported.
Journal ArticleDOI
Molecular MR imaging of melanoma angiogenesis with alphanubeta3-targeted paramagnetic nanoparticles
Anne H. Schmieder,Patrick M. Winter,Shelton D. Caruthers,Shelton D. Caruthers,Thomas D. Harris,Todd A. Williams,John S. Allen,Elizabeth K. Lacy,Huiying Zhang,Michael J. Scott,Grace Hu,J. David Robertson,Samuel A. Wickline,Gregory M. Lanza +13 more
TL;DR: The present study lowers the limit previously reported for detecting sparse biomarkers with molecular MRI in vivo, and may be employed to noninvasively detect very small regions of angiogenesis associated with nascent melanoma tumors, and to phenotype and stage early melanoma in a clinical setting.