J
John T. Fell
Researcher at University of Manchester
Publications - 101
Citations - 6118
John T. Fell is an academic researcher from University of Manchester. The author has contributed to research in topics: Gastric emptying & Dosage form. The author has an hindex of 38, co-authored 101 publications receiving 5865 citations.
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Determination of tablet strength by the diametral compression test
John T. Fell,JM Newton +1 more
TL;DR: It has been shown that to obtain reproducible results for the strength of tablets prepared at a given compression force, the tablet must break in such a manner that the tensile stress is the major stress.
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Floating dosage forms : an in vivo study demonstrating prolonged gastric retention
TL;DR: The results of this study suggest that, in the fed state, this freeze-dried calcium alginate multiple-unit FDF has potential for sustained drug delivery for either local or systemic purposes.
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An in vivo investigation into the suitability of pH dependent polymers for colonic targeting
TL;DR: In this article, the effect of a pH-dependent polymer coating, Eudragit S, on its ability to protect a model drug and control its release from rapidly disintegrating tablets has been examined in vitro.
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An evaluation of pectin as a carrier for drug targeting to the colon
TL;DR: In vitro experiments demonstrated that high methoxy pectin (pectin USP), when applied as a compression coat, proved capable of protecting a core tablet during conditions mimicking mouth-to-colon transit and was susceptible to enzymatic attack.
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Studies on pectin formulations for colonic drug delivery
TL;DR: It is suggested that either a high methoxy pectin formulation or a low methoxypectin with a carefully controlled amount of calcium should maximise colonie specificity by providing optimal protection of a drug during its transit to the colon and a high susceptibility to enzymic attack.