John T. Fell

TL;DR: It has been shown that to obtain reproducible results for the strength of tablets prepared at a given compression force, the tablet must break in such a manner that the tensile stress is the major stress.

TL;DR: The results of this study suggest that, in the fed state, this freeze-dried calcium alginate multiple-unit FDF has potential for sustained drug delivery for either local or systemic purposes.

TL;DR: In this article, the effect of a pH-dependent polymer coating, Eudragit S, on its ability to protect a model drug and control its release from rapidly disintegrating tablets has been examined in vitro.

TL;DR: In vitro experiments demonstrated that high methoxy pectin (pectin USP), when applied as a compression coat, proved capable of protecting a core tablet during conditions mimicking mouth-to-colon transit and was susceptible to enzymatic attack.

TL;DR: It is suggested that either a high methoxy pectin formulation or a low methoxypectin with a carefully controlled amount of calcium should maximise colonie specificity by providing optimal protection of a drug during its transit to the colon and a high susceptibility to enzymic attack.