John W. Beaber

TL;DR: Two SXT loci, designated setC and setD, whose predicted amino acid sequences were similar to those of the flagellar regulators FlhC and FlhD, were found to encode regulators that activate the transcription of genes required for SXT excision and transfer.

TL;DR: Both the Fab and scFv libraries show robust sequence diversity in target-specific binders and differential V-gene usage for each target tested, supporting the use of libraries that utilize multiple display formats and V- gene utilization to maximize antibody-binding diversity.

TL;DR: Data demonstrate that KBMA anthrax vaccines are well tolerated and elicit potent protective immune responses, and the use of KBMA vaccines may be broadly applicable to bacterial pathogens, especially those for which the correlates of protective immunity are unknown.

TL;DR: It is reported that disruption of the gene ftsX, which encodes the transmembrane domain of a putative ATP-binding cassette transporter, affords resistance to CXCL10-mediated antimicrobial effects against vegetative B. anthracis bacilli, and is the first description of a bacterial component critically involved in the ability of host chemokines to target and kill a bacterial pathogen.

TL;DR: It is postulate that Sap is involved in AP50c infectivity, most likely acting as the phage receptor, and that the spo0 genes may regulate synthesis of Sap and/or formation of the S layer.