J
Johnnie L. Leazer
Researcher at Merck & Co.
Publications - 9
Citations - 1253
Johnnie L. Leazer is an academic researcher from Merck & Co.. The author has contributed to research in topics: Trifluoromethyl & Protecting group. The author has an hindex of 5, co-authored 8 publications receiving 1215 citations.
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Journal ArticleDOI
Key green chemistry research areas—a perspective from pharmaceutical manufacturers
David J. C. Constable,Peter J. Dunn,John D. Hayler,Guy R. Humphrey,Johnnie L. Leazer,Russell J. Linderman,Kurt T. Lorenz,Julie B. Manley,Bruce A. Pearlman,Andrew S. Wells,Aleksey Zaks,Tony Y. Zhang +11 more
TL;DR: An assessment of the current state of the art in green chemistry and green engineering areas and to highlight areas for future improvement are provided.
Journal ArticleDOI
An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent
Johnnie L. Leazer,Raymond Cvetovich,Fuh-Rong Tsay,Ulf H. Dolling,Thomas Vickery,Donald Bachert +5 more
TL;DR: An improved and efficient bromination of 3,5-bis(trifluoromethylphenyl Grignard)benzene was developed and can be safely prepared and carried on to advanced intermediates.
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An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction
Zhiguo J. Song,Anthony O. King,Marjorie S. Waters,Fengrui Lang,Daniel Zewge,Matthew M. Bio,Johnnie L. Leazer,Gary Javadi,Amude M. Kassim,David M. Tschaen,Robert A. Reamer,Thorsten Rosner,Jennifer R. Chilenski,David J. Mathre,Ralph P. Volante,Richard D. Tillyer +15 more
TL;DR: An efficient asymmetric synthesis of a selective estrogen receptor modulator (SERM) that has a dihydrobenzoxathiin core structure bearing two stereogenic centers is reported.
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Removal of Common Organic Solvents from Aqueous Waste Streams via Supercritical CO2 Extraction: A Potential Green Approach to Sustainable Waste Management in the Pharmaceutical Industry
TL;DR: Since many supercritical fluids are gases at ambient temperature, the extract can be concentrated by simply venting the reaction mixture to a cyclone collection vessel, using appropriate safety protocols.
Journal ArticleDOI
syn-2,3-Disubstituted-2,3-dihydro-1,4-benzoxathiin rings: preparation from quinone ketals and 2-mercaptoethanols☆
Peter G. Dormer,Amude M. Kassim,Johnnie L. Leazer,Fengrui Lang,Feng Xu,Kimberly A. Savary,Edward G. Corley,Lisa DiMichele,Jimmy O. DaSilva,Anthony O. King,David M. Tschaen,Robert D. Larsen +11 more
TL;DR: In this article, a general method for the preparation of syn -2,3-disubstituted-2, 3-dihydro-1, 4-benzoxathiin rings from 2-mercaptoethanols and quinone ketals is presented.