K
Kurt T. Lorenz
Researcher at Eli Lilly and Company
Publications - 8
Citations - 1413
Kurt T. Lorenz is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Catalysis & Pericyclic reaction. The author has an hindex of 6, co-authored 8 publications receiving 1370 citations.
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Journal ArticleDOI
Key green chemistry research areas—a perspective from pharmaceutical manufacturers
David J. C. Constable,Peter J. Dunn,John D. Hayler,Guy R. Humphrey,Johnnie L. Leazer,Russell J. Linderman,Kurt T. Lorenz,Julie B. Manley,Bruce A. Pearlman,Andrew S. Wells,Aleksey Zaks,Tony Y. Zhang +11 more
TL;DR: An assessment of the current state of the art in green chemistry and green engineering areas and to highlight areas for future improvement are provided.
Journal ArticleDOI
Cation radical pericyclic reactions
Nathan L. Bauld,Dennis J. Bellville,Bijan Harirchian,Kurt T. Lorenz,Raul Pabon,Dan W. Reynolds,Wirth David Dale,Huh Sun Chiou,B. Kaye Marsh +8 more
Journal ArticleDOI
A Practical Synthesis of Biaryls via a Thermal Decarboxylative Pd-Catalyzed Cross-Coupling Reaction Operating at Moderate Temperature
David Mitchell,David M. Coppert,Humphrey A. Moynihan,Kurt T. Lorenz,Marie Kissane,Orla A. McNamara,Anita R. Maguire +6 more
TL;DR: In this article, the palladium-catalyzed decarboxylative cross-coupling of aminothiophene carboxylate and 1-bromo-4-chlorobenzene to produce 3-amino-2-(4)-chlorophenyl)thiophene (2) is described.
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A quality evaluation strategy for multi-sourced active pharmaceutical ingredient (API) starting materials
TL;DR: A strategy for purity method development and use test evaluation of starting materials to aid in establishing quality requirements is described and Phenyl methyl amino propanol (PMAP), a starting material that may be used for fluoxetine hydrochloride and atomoxetines hydrochlorides, is used to illustrate the quality evaluation strategy.
Journal ArticleDOI
Development of an NH4Cl-Catalyzed Ethoxy Ethyl Deprotection in Flow for the Synthesis of Merestinib
Michael O. Frederick,Joel R. Calvin,Richard F. Cope,Michael E. LeTourneau,Kurt T. Lorenz,Martin D. Johnson,Todd D. Maloney,Yangwei John Pu,Richard D. Miller,Lauren E. Cziesla +9 more
TL;DR: In this article, an NH4Cl-catalyzed ethoxy ethyl deprotection was developed for the synthesis of merestinib, a MET inhibitor, optimized for flow and has been used to synthesize over 100 kg of the target compound.